Chk1: A Double Agent in Cell Cycle Checkpoints

Hongtao Yu

Research output: Contribution to journalShort surveypeer-review

10 Scopus citations


Two cell cycle surveillance systems--the DNA damage checkpoint and the spindle checkpoint--guard against genomic instability. The protein kinase Chk1 is a well-established signal transducer in the DNA damage checkpoint. In this issue of Developmental Cell, Zachos et al. (2007) present evidence to indicate that Chk1 also plays a critical role in the spindle checkpoint, suggesting an interplay between the DNA damage and spindle checkpoints.

Original languageEnglish (US)
Pages (from-to)167-168
Number of pages2
JournalDevelopmental cell
Issue number2
StatePublished - Feb 2007

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Cell Biology


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