TY - JOUR
T1 - Children with Chronic Hepatitis B in the United States and Canada
AU - Hepatitis B Research Network
AU - Schwarz, Kathleen B.
AU - Cloonan, Yona Keich
AU - Ling, Simon C.
AU - Murray, Karen F.
AU - Rodriguez-Baez, Norberto
AU - Schwarzenberg, Sarah Jane
AU - Teckman, Jeffrey
AU - Ganova-Raeva, Lilia
AU - Rosenthal, Philip
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2020
Y1 - 2020
N2 - Objectives: To test the hypothesis that children with chronic hepatitis B living in the US and Canada would have international origins and characteristic hepatitis B virus (HBV) genotypes and laboratory profiles. Study design: Clinical characteristics of children enrolled in the Hepatitis B Research Network were collected from 7 US and Canadian centers. Results: Children (n = 343) with an age range of 1.0-17.8 years were enrolled; 78% of the children were Asian, 55% were adopted, and 97% had international origins with either the child or a parent born in 1 of 31 countries. The majority had HBV genotype B (43%) or C (32%), and the remainder had genotype A (5%), D (16%), E (4%), or multiple (<1%). Children with genotype B or C were more likely to be Asian (98% and 96%), more consistently hepatitis B envelope antigen positive (95% and 82%), had higher median HBV DNA levels (8.2 and 8.3 log10 IU/mL), and less frequently had elevated alanine aminotransferase values (43% and 57%) compared with children with other genotypes. The percentage of hepatitis B envelope antigen positivity and of those with HBV DNA ≥6 log10 IU/mL declined with age. Conclusions: The majority of children in the Hepatitis B Research Network have HBV genotypes that reflect their international origins. Clinical and laboratory data differ substantially by patient age and HBV genotype. Use of these data can help drive the development of optimal strategies to manage and treat children with chronic hepatitis B.
AB - Objectives: To test the hypothesis that children with chronic hepatitis B living in the US and Canada would have international origins and characteristic hepatitis B virus (HBV) genotypes and laboratory profiles. Study design: Clinical characteristics of children enrolled in the Hepatitis B Research Network were collected from 7 US and Canadian centers. Results: Children (n = 343) with an age range of 1.0-17.8 years were enrolled; 78% of the children were Asian, 55% were adopted, and 97% had international origins with either the child or a parent born in 1 of 31 countries. The majority had HBV genotype B (43%) or C (32%), and the remainder had genotype A (5%), D (16%), E (4%), or multiple (<1%). Children with genotype B or C were more likely to be Asian (98% and 96%), more consistently hepatitis B envelope antigen positive (95% and 82%), had higher median HBV DNA levels (8.2 and 8.3 log10 IU/mL), and less frequently had elevated alanine aminotransferase values (43% and 57%) compared with children with other genotypes. The percentage of hepatitis B envelope antigen positivity and of those with HBV DNA ≥6 log10 IU/mL declined with age. Conclusions: The majority of children in the Hepatitis B Research Network have HBV genotypes that reflect their international origins. Clinical and laboratory data differ substantially by patient age and HBV genotype. Use of these data can help drive the development of optimal strategies to manage and treat children with chronic hepatitis B.
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U2 - 10.1016/j.jpeds.2015.08.021
DO - 10.1016/j.jpeds.2015.08.021
M3 - Article
C2 - 26364985
AN - SCOPUS:85027926289
SN - 0022-3476
SP - 1287-1294.e2
JO - Journal of Pediatrics
JF - Journal of Pediatrics
ER -