Chikungunya-induced cell death is limited by ER and oxidative stress-induced autophagy

Pierre Emmanuel Joubert; Scott Werneke; Claire De La Calle; Florence Guivel-Benhassine; Alessandra Giodini; Lucie Peduto; Beth Levine; Olivier Schwartz; Deborah Lenschow; Matthew L. Albert

doi:10.4161/auto.20751

Chikungunya-induced cell death is limited by ER and oxidative stress-induced autophagy

Pierre Emmanuel Joubert, Scott Werneke, Claire De La Calle, Florence Guivel-Benhassine, Alessandra Giodini, Lucie Peduto, Beth Levine, Olivier Schwartz, Deborah Lenschow, Matthew L. Albert

Research output: Contribution to journal › Short survey › peer-review

34 Scopus citations

Abstract

It has been recognized that macroautophagy constitutes an important survival mechanism that allows both the maintenance of cellular homeostasis and the regulation of programmed cell death pathways (e.g., apoptosis). Although several pathogens have been described to induce autophagy, the prosurvival function of this process in infectious models remains poorly characterized. Our recent studies on chikungunya virus (CHIKV), the causative agent of major epidemics in India, Southeast Asia and southern Europe, reveal a novel mechanism by which autophagy limits the cytopathic effects of CHIKV by impinging upon virus-induced cell death pathways.

Original language	English (US)
Pages (from-to)	1261-1263
Number of pages	3
Journal	Autophagy
Volume	8
Issue number	8
DOIs	https://doi.org/10.4161/auto.20751
State	Published - Aug 2012

Keywords

Apoptosis
Autophagy
Chikungunya
Endoplasmic reticulum stress and oxidative stress

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.4161/auto.20751

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title = "Chikungunya-induced cell death is limited by ER and oxidative stress-induced autophagy",

abstract = "It has been recognized that macroautophagy constitutes an important survival mechanism that allows both the maintenance of cellular homeostasis and the regulation of programmed cell death pathways (e.g., apoptosis). Although several pathogens have been described to induce autophagy, the prosurvival function of this process in infectious models remains poorly characterized. Our recent studies on chikungunya virus (CHIKV), the causative agent of major epidemics in India, Southeast Asia and southern Europe, reveal a novel mechanism by which autophagy limits the cytopathic effects of CHIKV by impinging upon virus-induced cell death pathways.",

keywords = "Apoptosis, Autophagy, Chikungunya, Endoplasmic reticulum stress and oxidative stress",

author = "Joubert, {Pierre Emmanuel} and Scott Werneke and {De La Calle}, Claire and Florence Guivel-Benhassine and Alessandra Giodini and Lucie Peduto and Beth Levine and Olivier Schwartz and Deborah Lenschow and Albert, {Matthew L.}",

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doi = "10.4161/auto.20751",

language = "English (US)",

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pages = "1261--1263",

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T1 - Chikungunya-induced cell death is limited by ER and oxidative stress-induced autophagy

AU - Joubert, Pierre Emmanuel

AU - Werneke, Scott

AU - De La Calle, Claire

AU - Guivel-Benhassine, Florence

AU - Giodini, Alessandra

AU - Peduto, Lucie

AU - Levine, Beth

AU - Schwartz, Olivier

AU - Lenschow, Deborah

AU - Albert, Matthew L.

PY - 2012/8

Y1 - 2012/8

N2 - It has been recognized that macroautophagy constitutes an important survival mechanism that allows both the maintenance of cellular homeostasis and the regulation of programmed cell death pathways (e.g., apoptosis). Although several pathogens have been described to induce autophagy, the prosurvival function of this process in infectious models remains poorly characterized. Our recent studies on chikungunya virus (CHIKV), the causative agent of major epidemics in India, Southeast Asia and southern Europe, reveal a novel mechanism by which autophagy limits the cytopathic effects of CHIKV by impinging upon virus-induced cell death pathways.

AB - It has been recognized that macroautophagy constitutes an important survival mechanism that allows both the maintenance of cellular homeostasis and the regulation of programmed cell death pathways (e.g., apoptosis). Although several pathogens have been described to induce autophagy, the prosurvival function of this process in infectious models remains poorly characterized. Our recent studies on chikungunya virus (CHIKV), the causative agent of major epidemics in India, Southeast Asia and southern Europe, reveal a novel mechanism by which autophagy limits the cytopathic effects of CHIKV by impinging upon virus-induced cell death pathways.

KW - Apoptosis

KW - Autophagy

KW - Chikungunya

KW - Endoplasmic reticulum stress and oxidative stress

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DO - 10.4161/auto.20751

M3 - Short survey

C2 - 22836517

AN - SCOPUS:84866138831

SN - 1554-8627

VL - 8

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JO - Autophagy

JF - Autophagy

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ER -

Chikungunya-induced cell death is limited by ER and oxidative stress-induced autophagy

Abstract

Keywords

ASJC Scopus subject areas

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