TY - JOUR
T1 - Chemiluminescent 1,2-Dioxetane Iridium Complexes for Near-Infrared Oxygen Sensing
AU - Kagalwala, Husain N.
AU - Gerberich, Jeni
AU - Smith, Chancellor J.
AU - Mason, Ralph P.
AU - Lippert, Alexander R.
N1 - Publisher Copyright:
© 2022 Wiley-VCH GmbH
PY - 2022/3/14
Y1 - 2022/3/14
N2 - Chemiluminescent iridium-based sensors which demonstrate oxygen dependent responses have been developed. The molecular probes, named IrCL-1, IrCL-2 and IrCL-3 consist of oxygen-sensitive iridium complexes attached to a spiroadamantane 1,2 dioxetane and operate via energy transfer from the chemiexcited benzoate to the corresponding iridium(III) complex. Complexing the iridium(III) center with π-extended ligands results in emission in the biologically relevant, near-infrared (NIR) region. All probes demonstrate varying oxygen tolerance, with IrCL-1 being the most oxygen sensitive. These probes have been further utilized for in vitro ratiometric imaging of oxygen, as well as for intraperitoneal, intramuscular and intratumoral imaging in live mice. To our knowledge, these are the first iridium-based chemiluminescent probes that have been employed for in vitro ratiometric oxygen sensing, and for in vivo tumor imaging.
AB - Chemiluminescent iridium-based sensors which demonstrate oxygen dependent responses have been developed. The molecular probes, named IrCL-1, IrCL-2 and IrCL-3 consist of oxygen-sensitive iridium complexes attached to a spiroadamantane 1,2 dioxetane and operate via energy transfer from the chemiexcited benzoate to the corresponding iridium(III) complex. Complexing the iridium(III) center with π-extended ligands results in emission in the biologically relevant, near-infrared (NIR) region. All probes demonstrate varying oxygen tolerance, with IrCL-1 being the most oxygen sensitive. These probes have been further utilized for in vitro ratiometric imaging of oxygen, as well as for intraperitoneal, intramuscular and intratumoral imaging in live mice. To our knowledge, these are the first iridium-based chemiluminescent probes that have been employed for in vitro ratiometric oxygen sensing, and for in vivo tumor imaging.
KW - Chemiluminescence
KW - Energy Transfer
KW - Iridium Oxygen Sensor
KW - Ratiometric
KW - Spiroadamantane 1,2-Dioxetanes
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U2 - 10.1002/anie.202115704
DO - 10.1002/anie.202115704
M3 - Article
C2 - 35037345
AN - SCOPUS:85123569730
SN - 1433-7851
VL - 61
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 12
M1 - e202115704
ER -