Chemical modulation of glycerolipid signaling and metabolic pathways

Sarah A. Scott, Thomas P. Mathews, Pavlina T. Ivanova, Craig W. Lindsley, H. Alex Brown

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations


Thirty years ago, glycerolipids captured the attention of biochemical researchers as novel cellular signaling entities. We now recognize that these biomolecules occupy signaling nodes critical to a number of physiological and pathological processes. Thus, glycerolipid-metabolizing enzymes present attractive targets for new therapies. A number of fields - ranging from neuroscience and cancer to diabetes and obesity - have elucidated the signaling properties of glycerolipids. The biochemical literature teems with newly emerging small molecule inhibitors capable of manipulating glycerolipid metabolism and signaling. This ever-expanding pool of chemical modulators appears daunting to those interested in exploiting glycerolipid-signaling pathways in their model system of choice. This review distills the current body of literature surrounding glycerolipid metabolism into a more approachable format, facilitating the application of small molecule inhibitors to novel systems. This article is part of a Special Issue entitled Tools to study lipid functions.

Original languageEnglish (US)
Pages (from-to)1060-1084
Number of pages25
JournalBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Issue number8
StatePublished - Aug 2014
Externally publishedYes


  • Autotaxin
  • Fatty acyltransferase
  • Glycerolipid
  • Inhibitor
  • Lipase
  • Lipid kinase
  • Lipin
  • Metabolism
  • Phospholipase

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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