Abstract
Background: The objective of this study is to characterize the relationship between ICP and EEG Methods: Simultaneous ICP and EEG data were obtained from burst-suppressed patients and segmented by EEG bursts. Segments were categorized as increasing/decreasing and peak/valley to investigate relationship between ICP changes and EEG burst duration. A generalized ICP response was obtained by averaging all segments time-aligned at burst onsets. A vasodilatation index (VDI) was derived from the ICP pulse waveform and calculated on a sliding interval to investigate cerebrovascular changes post-burst. Results: Data from two patients contained 309 bursts. 246 ICP segments initially increased, of which 154 peaked. 63 ICP segments decreased, and zero reached a valley. The change in ICP (0.54 ± 0.85 mmHg) was significantly correlated with the burst duration (p < 0.001). Characterization of the ICP segments showed a peak at 8.1 s and a return to baseline at 14.7 s. The VDI for increasing segments was significantly elevated (median 0.56, IQR 0.31, p < 0.001) and correlated with burst duration (p < 0.001). Conclusions: Changes in the ICP and pulse waveform shape after EEG burst suggest that these signals can be related within the context of neurovascular coupling. Significance: Existence of a physiological relationship between ICP and EEG may allow the study of neurovascular coupling in acute brain injury patients.
Original language | English (US) |
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Pages (from-to) | 212-220 |
Number of pages | 9 |
Journal | Neurocritical Care |
Volume | 22 |
Issue number | 2 |
DOIs | |
State | Published - Apr 2015 |
Externally published | Yes |
Keywords
- Acute brain injury
- Electroencephalogram
- Intracranial pressure
- Multi-modality monitoring
- Neurovascular coupling
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine
- Clinical Neurology