@inproceedings{2751ddda79444c5faf90da1cf074f70c,
title = "Characterization of quenched fluorescent triple helical peptides for MMP-2 and MMP-9 optical imaging",
abstract = "The prevalence of the gelatinases, MMP-2 and MMP-9, in many human tumors, including breast, colorectal, prostate and gastric cancer, make them an attractive target for molecular imaging. A self assembling homotrimeric triple helical peptide (THP), incorporating sequences from type V collagen with high specificity to MMP-2 and MMP-9, was previously developed. To investigate the viability of a THP for gelatinase imaging, we conjugated 5FAM to ε-amino groups of lysine flanking the hydrolysis site and subjected this substrate (THP-5FAM) to vitro analysis. The synthesis and in vitro results was presented.",
keywords = "Cancer, Fluorescence, Gelatinase, MMP, Optical imaging",
author = "Cheney, {Philip P.} and Fields, {Gregg B.} and Samuel Achilefu and Edwards, {W. Barry}",
year = "2009",
doi = "10.1117/12.810096",
language = "English (US)",
isbn = "9780819474360",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications",
note = "Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications ; Conference date: 26-01-2009 Through 29-01-2009",
}