Abstract
Near-normal glucoregulation was maintained in five patients with juvenile-onset diabetes mellitus for 4-5 wk with a preprogrammed, continuous, subcutaneous insulin infusion using a portable battery-powered infusion pump. This form of therapy significantly lowered immunoreactive glucagon (IRG) levels below those observed while on conventional insulin treatment at several times during the 24-h profile. The maximum IRG levels were also reduced in all five subjects. Thus, a flexible system of insulin delivery, as is provided by certain open-loop pump systems, can overcome inappropriate glucagon secretion that occurs with conventional insulin therapy.
Original language | English (US) |
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Pages (from-to) | 1033-1035 |
Number of pages | 3 |
Journal | Diabetes |
Volume | 28 |
Issue number | 11 |
DOIs | |
State | Published - 1979 |
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism