Cervical Lymph Node Metastasis in Adenoid Cystic Carcinoma of the Larynx: A Collective International Review

Andrés Coca-Pelaz, Leon Barnes, Alessandra Rinaldo, Antonio Cardesa, Jatin P. Shah, Juan P. Rodrigo, Carlos Suárez, Jean Anderson Eloy, Justin A. Bishop, Kenneth O. Devaney, Lester D.R. Thompson, Bruce M. Wenig, Primož Strojan, Marc Hamoir, Patrick J. Bradley, Douglas R. Gnepp, Carl E. Silver, Pieter J. Slootweg, Asterios Triantafyllou, Vincent Vander PoortenMichelle D. Williams, Alena Skálová, Henrik Hellquist, Afshin Teymoortash, Jesus E. Medina, K. Thomas Robbins, Karen T. Pitman, Luiz P. Kowalski, Remco de Bree, William M. Mendenhall, Robert P. Takes, Alfio Ferlito

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Adenoid cystic carcinoma (AdCC) of the head and neck is a well-recognized pathologic entity that rarely occurs in the larynx. Although the 5-year locoregional control rates are high, distant metastasis has a tendency to appear more than 5 years post treatment. Because AdCC of the larynx is uncommon, it is difficult to standardize a treatment protocol. One of the controversial points is the decision whether or not to perform an elective neck dissection on these patients. Because there is contradictory information about this issue, we have critically reviewed the literature from 1912 to 2015 on all reported cases of AdCC of the larynx in order to clarify this issue. During the most recent period of our review (1991–2015) with a more exact diagnosis of the tumor histology, 142 cases were observed of AdCC of the larynx, of which 91 patients had data pertaining to lymph node status. Eleven of the 91 patients (12.1%) had nodal metastasis and, based on this low proportion of patients, routine elective neck dissection is therefore not recommended.

Original languageEnglish (US)
Pages (from-to)553-579
Number of pages27
JournalAdvances in Therapy
Issue number4
StatePublished - Apr 1 2016


  • Adenoid cystic carcinoma
  • Clinical protocols
  • Elective neck dissection
  • Larynx
  • Lymph node metastasis
  • Neck
  • Oncology
  • Treatment

ASJC Scopus subject areas

  • Pharmacology (medical)


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