Cerebrospinal fluid variables among alcoholics lack seasonal variation

A. Roy, B. Adinoff, J. DeJong, M. Linnoila

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Seasonal influences on indices of serotonergic function, including cerebrospinal fluid (CSF) concentrations of the serotonin metabolite 5‐hydroxyindoleacetic acid (5‐HIAA), have been reported in psychiatric patients and healthy volunteers. We examined seasonal differences in CSF concentrations of 5‐HIAA among 135 alcoholics admitted to a research ward who had a lumbar puncture. No significant seasonal differences were found for either CSF concentrations of 5‐HIAA or CSF concentrations of other monoamine metabolites or peptides. The possible explanations for these negative findings are discussed.

Original languageEnglish (US)
Pages (from-to)579-582
Number of pages4
JournalActa Psychiatrica Scandinavica
Issue number6
StatePublished - Dec 1991


  • alcoholism
  • cerebrospinal fluid
  • season
  • serotonin

ASJC Scopus subject areas

  • Psychiatry and Mental health


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