TY - JOUR
T1 - Cerebral blood volume in Alzheimer's disease and correlation with tissue structural integrity
AU - Uh, Jinsoo
AU - Lewis-Amezcua, Kelly
AU - Martin-Cook, Kristin
AU - Cheng, Yamei
AU - Weiner, Myron
AU - Diaz-Arrastia, Ramon
AU - Devous, Michael
AU - Shen, Dinggang
AU - Lu, Hanzhang
N1 - Funding Information:
The authors are grateful to Dr. Guanghua Xiao for assistance with data analysis. This work was supported by Alzheimer Association NIRG 05-14056, NIH R21 NS054916, NIH P30 AG12300, and the Texas Instruments Foundation.
PY - 2010/12
Y1 - 2010/12
N2 - A vascular component is increasingly recognized as important in Alzheimer's disease (AD). We measured cerebral blood volume (CBV) in patients with probable AD or Mild Cognitive Impairment (MCI) and in elderly non-demented subjects using a recently developed Vascular-Space-Occupancy (VASO) MRI technique. While both gray and white matters were examined, significant CBV deficit regions were primarily located in white matter, specifically in frontal and parietal lobes, in which CBV was reduced by 20% in the AD/MCI group. The regions with CBV deficit also showed reduced tissue structural integrity as indicated by increased apparent diffusion coefficients, whereas in regions without CBV deficits no such correlation was found. Subjects with lower CBV tended to have more white matter lesions in FLAIR MRI images and showed slower psychomotor speed. These data suggest that the vascular contribution in AD is primarily localized to frontal/parietal white matter and is associated with brain tissue integrity.
AB - A vascular component is increasingly recognized as important in Alzheimer's disease (AD). We measured cerebral blood volume (CBV) in patients with probable AD or Mild Cognitive Impairment (MCI) and in elderly non-demented subjects using a recently developed Vascular-Space-Occupancy (VASO) MRI technique. While both gray and white matters were examined, significant CBV deficit regions were primarily located in white matter, specifically in frontal and parietal lobes, in which CBV was reduced by 20% in the AD/MCI group. The regions with CBV deficit also showed reduced tissue structural integrity as indicated by increased apparent diffusion coefficients, whereas in regions without CBV deficits no such correlation was found. Subjects with lower CBV tended to have more white matter lesions in FLAIR MRI images and showed slower psychomotor speed. These data suggest that the vascular contribution in AD is primarily localized to frontal/parietal white matter and is associated with brain tissue integrity.
KW - Alzheimer's disease
KW - Cerebral blood flow
KW - Cerebral blood volume
KW - MRI
KW - Tissue integrity
KW - VASO
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U2 - 10.1016/j.neurobiolaging.2008.12.010
DO - 10.1016/j.neurobiolaging.2008.12.010
M3 - Article
C2 - 19200623
AN - SCOPUS:78650172553
SN - 0197-4580
VL - 31
SP - 2038
EP - 2046
JO - Neurobiology of Aging
JF - Neurobiology of Aging
IS - 12
ER -