Cerebral blood volume in Alzheimer's disease and correlation with tissue structural integrity

Jinsoo Uh, Kelly Lewis-Amezcua, Kristin Martin-Cook, Yamei Cheng, Myron Weiner, Ramon Diaz-Arrastia, Michael Devous, Dinggang Shen, Hanzhang Lu

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


A vascular component is increasingly recognized as important in Alzheimer's disease (AD). We measured cerebral blood volume (CBV) in patients with probable AD or Mild Cognitive Impairment (MCI) and in elderly non-demented subjects using a recently developed Vascular-Space-Occupancy (VASO) MRI technique. While both gray and white matters were examined, significant CBV deficit regions were primarily located in white matter, specifically in frontal and parietal lobes, in which CBV was reduced by 20% in the AD/MCI group. The regions with CBV deficit also showed reduced tissue structural integrity as indicated by increased apparent diffusion coefficients, whereas in regions without CBV deficits no such correlation was found. Subjects with lower CBV tended to have more white matter lesions in FLAIR MRI images and showed slower psychomotor speed. These data suggest that the vascular contribution in AD is primarily localized to frontal/parietal white matter and is associated with brain tissue integrity.

Original languageEnglish (US)
Pages (from-to)2038-2046
Number of pages9
JournalNeurobiology of Aging
Issue number12
StatePublished - Dec 2010


  • Alzheimer's disease
  • Cerebral blood flow
  • Cerebral blood volume
  • MRI
  • Tissue integrity
  • VASO

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology


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