Cerebral Blood Flow Monitoring in High-Risk Fetal and Neonatal Populations

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6 Scopus citations


Cerebrovascular pressure autoregulation promotes stable cerebral blood flow (CBF) across a range of arterial blood pressures. Cerebral autoregulation (CA) is a developmental process that reaches maturity around term gestation and can be monitored prenatally with both Doppler ultrasound and magnetic resonance imaging (MRI) techniques. Postnatally, there are key advantages and limitations to assessing CA with Doppler ultrasound, MRI, and near-infrared spectroscopy. Here we review these CBF monitoring techniques as well as their application to both fetal and neonatal populations at risk of perturbations in CBF. Specifically, we discuss CBF monitoring in fetuses with intrauterine growth restriction, anemia, congenital heart disease, neonates born preterm and those with hypoxic-ischemic encephalopathy. We conclude the review with insights into the future directions in this field with an emphasis on collaborative science and precision medicine approaches.

Original languageEnglish (US)
Article number748345
JournalFrontiers in Pediatrics
StatePublished - Jan 11 2022


  • cerebral autoregulation
  • cerebroplacental Doppler
  • congenital heart disease
  • fetal MRI
  • fetal brain
  • hypoxic ischemia encephalopathy (HIE)
  • near-infrared spectroscopy
  • neonatal brain

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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