Cerebral blood flow during static exercise in humans

H. B. Rogers, T. Schroeder, N. H. Secher, J. H. Mitchell

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39 Scopus citations


Cerebral blood flow (CBF) was determined in humans at rest and during four consecutive unilateral static contractions of the knee extensors. Each contraction was maintained for 3 min 15 s with the subjects in a semisupine position. The contractions corresponded to 8, 16, 24, and 32% of the maximal voluntary contraction (MVC) and utilized alternate legs. CBF (measured by the 133Xe clearance technique) was expressed by a noncompartmental flow index (ISI). Heart rate and mean arterial pressure increased from resting values of 73 (55-80) beats/min and 88 (74-104) mmHg to 106 (86-138) beats/min and 124 (102-146) mmHg, respectively (P < 0.0005), during the contraction at 32% MVC. Arterial PCO2 and central venous pressure did not change. Corrected to the average resting PCO2, CBF during control was 55 (35-73) ml · 100 g-1 · min-1 and remained constant during contractions. Cerebral vascular resistance increased from 1.5 (1.0-2.2) to 2.4 (1.4-3.0) mmHg · 100 g · min · ml-1 (P < 0.025) at 32% of MVC. There was no difference in CBF between the two hemispheres at rest or during exercise. In contrast to dynamic leg exercise, static leg exercise is not associated with an increase in global CBF when measured by the 133Xe clearance technique.

Original languageEnglish (US)
Pages (from-to)2358-2361
Number of pages4
JournalJournal of applied physiology
Issue number6
StatePublished - 1990


  • arterial blood pressure
  • arterial carbon dioxide tension
  • central venous pressure
  • cerebral vascular resistance
  • heart rate
  • rating of perceived exertion

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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