Cerebral blood flow changes during sodium-lactate-induced panic attacks

R. S. Stewart, M. D. Devous, A. J. Rush, L. Lane, F. J. Bonte

Research output: Contribution to journalArticlepeer-review

109 Scopus citations


Dynamic single-photon emission computed axial tomography (CAT) with inhaled xenon-133 was used to measure regional cerebral blood flow in 10 drug-free patients with DSM-III-diagnosed panic disorder and in five normal control subjects. All subjects underwent regional cerebral blood flow studies while at rest or during normal saline infusion and during sodium lactate infusion. Six of the 10 patients and none of the control subjects experienced lactate-induced panic attacks. Lactate infusion markedly raised hemispheric blood flow levels in both control subjects and patients who did not panic. Patients who did panic experienced either a minimal increase or a decrease in hemispheric blood flow.

Original languageEnglish (US)
Pages (from-to)442-449
Number of pages8
JournalAmerican Journal of Psychiatry
Issue number4
StatePublished - 1988

ASJC Scopus subject areas

  • Psychiatry and Mental health


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