Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma

Yu Fang; Xiaoxin Chen; Manisha Bajpai; Amit Verma; Kiron M. Das; Rhonda F. Souza; Katherine S. Garman; Claire L. Donohoe; Naoimh J. O'Farrell; John V. Reynolds; Katerina Dvorak

doi:10.1111/nyas.12249

Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma

Yu Fang, Xiaoxin Chen, Manisha Bajpai, Amit Verma, Kiron M. Das, Rhonda F. Souza, Katherine S. Garman, Claire L. Donohoe, Naoimh J. O'Farrell, John V. Reynolds, Katerina Dvorak

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

This paper presents commentaries on animal models used for Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) research; acid- and bile-induced chromosomal instability and clonal selection during the progression of BE to EAC; how the components of gastric refluxate, especially acid and bile salts, promote carcinogenesis in metaplastic BE; genome-wide changes in DNA methylation and transcription involved in BE carcinogenesis; the potential role of miRNA in the development of BE and EAC; the effect of inflammatory cytokines linked to obesity on the activation of cell-death pathways and cell survival in BE and esophageal cancer; and the role of autophagy in esophageal cancer development.

Original language	English (US)
Pages (from-to)	187-199
Number of pages	13
Journal	Annals of the New York Academy of Sciences
Volume	1300
Issue number	1
DOIs	https://doi.org/10.1111/nyas.12249
State	Published - Oct 2013

Keywords

Autophagy
Barrett's esophagus
DNA methylation
Esophageal adenocarcinoma
Obesity

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

Access to Document

10.1111/nyas.12249

Cite this

@article{991626a8a1ac4dfaafd82d1318ae9e22,

title = "Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma",

abstract = "This paper presents commentaries on animal models used for Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) research; acid- and bile-induced chromosomal instability and clonal selection during the progression of BE to EAC; how the components of gastric refluxate, especially acid and bile salts, promote carcinogenesis in metaplastic BE; genome-wide changes in DNA methylation and transcription involved in BE carcinogenesis; the potential role of miRNA in the development of BE and EAC; the effect of inflammatory cytokines linked to obesity on the activation of cell-death pathways and cell survival in BE and esophageal cancer; and the role of autophagy in esophageal cancer development.",

keywords = "Autophagy, Barrett's esophagus, DNA methylation, Esophageal adenocarcinoma, Obesity",

author = "Yu Fang and Xiaoxin Chen and Manisha Bajpai and Amit Verma and Das, {Kiron M.} and Souza, {Rhonda F.} and Garman, {Katherine S.} and Donohoe, {Claire L.} and O'Farrell, {Naoimh J.} and Reynolds, {John V.} and Katerina Dvorak",

year = "2013",

month = oct,

doi = "10.1111/nyas.12249",

language = "English (US)",

volume = "1300",

pages = "187--199",

journal = "Annals of the New York Academy of Sciences",

issn = "0077-8923",

publisher = "Wiley-Blackwell",

number = "1",

}

TY - JOUR

T1 - Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma

AU - Fang, Yu

AU - Chen, Xiaoxin

AU - Bajpai, Manisha

AU - Verma, Amit

AU - Das, Kiron M.

AU - Souza, Rhonda F.

AU - Garman, Katherine S.

AU - Donohoe, Claire L.

AU - O'Farrell, Naoimh J.

AU - Reynolds, John V.

AU - Dvorak, Katerina

PY - 2013/10

Y1 - 2013/10

N2 - This paper presents commentaries on animal models used for Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) research; acid- and bile-induced chromosomal instability and clonal selection during the progression of BE to EAC; how the components of gastric refluxate, especially acid and bile salts, promote carcinogenesis in metaplastic BE; genome-wide changes in DNA methylation and transcription involved in BE carcinogenesis; the potential role of miRNA in the development of BE and EAC; the effect of inflammatory cytokines linked to obesity on the activation of cell-death pathways and cell survival in BE and esophageal cancer; and the role of autophagy in esophageal cancer development.

AB - This paper presents commentaries on animal models used for Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) research; acid- and bile-induced chromosomal instability and clonal selection during the progression of BE to EAC; how the components of gastric refluxate, especially acid and bile salts, promote carcinogenesis in metaplastic BE; genome-wide changes in DNA methylation and transcription involved in BE carcinogenesis; the potential role of miRNA in the development of BE and EAC; the effect of inflammatory cytokines linked to obesity on the activation of cell-death pathways and cell survival in BE and esophageal cancer; and the role of autophagy in esophageal cancer development.

KW - Autophagy

KW - Barrett's esophagus

KW - DNA methylation

KW - Esophageal adenocarcinoma

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=84885440265&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885440265&partnerID=8YFLogxK

U2 - 10.1111/nyas.12249

DO - 10.1111/nyas.12249

M3 - Article

C2 - 24117642

AN - SCOPUS:84885440265

SN - 0077-8923

VL - 1300

SP - 187

EP - 199

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

IS - 1

ER -

Cellular origins and molecular mechanisms of Barrett's esophagus and esophageal adenocarcinoma

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this