Cellular and molecular responses to topoisomerase I poisons: Exploiting synergy for improved radiotherapy

Arts & Humanities

• Radiotherapy 100%
• Synergy 80%
• Poison 79%
• Radiation 58%
• Cells 49%
• Drugs 29%
• Cancer 27%
• Activation 25%
• DNA 22%
• Poisoning 20%
• Lesion 16%
• Pathway 15%
• Killing 10%
• Protease 10%
• Damage 10%
• S Phase 9%
• Enzymes 8%
• Transduction 7%
• Protein 7%
• Insult 6%
• Elucidation 6%
• Metabolism 5%
• Replication 5%
• Stimulation 5%
• Efficacy 5%
• Nucleus 5%
• Alteration 5%
• Gene 5%

Medicine & Life Sciences

• Type I DNA Topoisomerase 91%
• Poisons 52%
• Radiotherapy 48%
• Ionizing Radiation 36%
• Poisoning 13%
• Type II DNA Topoisomerase 11%
• Pharmaceutical Preparations 10%
• Calpain 10%
• Apoptosis 10%
• Neoplasms 8%
• Substrate Cycling 7%
• Aphidicolin 6%
• Topotecan 6%
• quinone 5%
• DNA 4%
• NAD 4%
• DNA Replication 4%
• S Phase 4%
• Oxidoreductases 4%
• DNA Damage 3%
• Peptide Hydrolases 3%
• Cell Cycle 3%
• Signal Transduction 3%
• X-Rays 3%
• Necrosis 3%
• Cell Death 3%
• Enzymes 2%
• In Vitro Techniques 1%
• Genes 1%
• Proteins 1%

Chemical Compounds

• Ionizing Radiation 85%
• Poison 81%
• Antiapoptotic 28%
• Drug 26%
• Modification 16%
• Aphidicolin 16%
• Topotecan 15%
• NAD(P)H 13%
• Genotoxic 11%
• Signal Transduction 10%
• Cell Death 10%
• Quinone 9%
• Pharmacological Metabolism 7%
• Protein 4%