Cellular and humoral immunity combine to determine the outcome following exposure to hepatitis virus and are implicated in the proposed pathogenetic mechanism for acute and chronic hepatitis. Although antibody to HB(s)Ag is found in virtually all following recovery from hepatitis B, a cell mediated response to HB(s)Ag can be detected in most patients during the acute phase, and it has been suggested that this may cause the acute hepatic damage by an attack on virus infected cells. Patients who have chronic active hepatitis also frequently have cell mediated immunity to HB(s)Ag, regardless of whether the antigen can be detected in their sera; thus, previous exposure to hepatitis B may be important in initiating the disease even in antigen negative cases. Cell mediated responses to liver specific lipoprotein, a membrane antigen, occur transiently in many patients who have acute hepatitis and are persistent in virtually all with untreated chronic active hepatitis. The relative importances and precise mechanisms of these immune responses in the pathogenesis of acute and chronic hepatitis remain to be determined.
|Original language||English (US)|
|Number of pages||4|
|Journal||American journal of clinical pathology|
|Issue number||5 sup|
|State||Published - Jan 1 1976|
ASJC Scopus subject areas
- Pathology and Forensic Medicine