TY - JOUR
T1 - Cell-intrinsic signals that regulate adult neurogenesis in vivo
T2 - Insights from inducible approaches
AU - Johnson, Madeleine A.
AU - Ables, Jessica L.
AU - Eisch, Amelia J.
PY - 2009/5
Y1 - 2009/5
N2 - The process by which adult neural stem cells generate new and functionally integrated neurons in the adult mammalian brain has been intensely studied, but much more remains to be discovered. It is known that neural progenitors progress through distinct stages to become mature neurons, and this progression is tightly controlled by cell-cell interactions and signals in the neurogenic niche. However, less is known about the cell-intrinsic signaling required for proper progression through stages of adult neurogenesis. Techniques have recently been developed to manipulate genes specifically in adult neural stem cells and progenitors in vivo, such as the use of inducible transgenic mice and viral-mediated gene transduction. A critical mass of publications utilizing these techniques has been reached, making it timely to review which molecules are now known to play a cell-intrinsic role in regulating adult neurogenesis in vivo. By drawing attention to these isolated molecules (e.g. Notch), we hope to stimulate a broad effort to understand the complex and compelling cascades of intrinsic signaling molecules important to adult neurogenesis. Understanding this process opens the possibility of understanding brain functions subserved by neurogenesis, such as memory, and also of harnessing neural stem cells for repair of the diseased and injured brain.
AB - The process by which adult neural stem cells generate new and functionally integrated neurons in the adult mammalian brain has been intensely studied, but much more remains to be discovered. It is known that neural progenitors progress through distinct stages to become mature neurons, and this progression is tightly controlled by cell-cell interactions and signals in the neurogenic niche. However, less is known about the cell-intrinsic signaling required for proper progression through stages of adult neurogenesis. Techniques have recently been developed to manipulate genes specifically in adult neural stem cells and progenitors in vivo, such as the use of inducible transgenic mice and viral-mediated gene transduction. A critical mass of publications utilizing these techniques has been reached, making it timely to review which molecules are now known to play a cell-intrinsic role in regulating adult neurogenesis in vivo. By drawing attention to these isolated molecules (e.g. Notch), we hope to stimulate a broad effort to understand the complex and compelling cascades of intrinsic signaling molecules important to adult neurogenesis. Understanding this process opens the possibility of understanding brain functions subserved by neurogenesis, such as memory, and also of harnessing neural stem cells for repair of the diseased and injured brain.
KW - Cdk5
KW - Inducible transgenics
KW - Notch
KW - Stem cells
KW - Subgranular zone
KW - Viral-mediated gene transfer
UR - http://www.scopus.com/inward/record.url?scp=66549101396&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=66549101396&partnerID=8YFLogxK
U2 - 10.5483/BMBRep.2009.42.5.245
DO - 10.5483/BMBRep.2009.42.5.245
M3 - Short survey
C2 - 19470237
AN - SCOPUS:66549101396
SN - 1976-6696
VL - 42
SP - 245
EP - 259
JO - BMB Reports
JF - BMB Reports
IS - 5
ER -