Ceftolozane/tazobactam sensitivity patterns in Pseudomonas aeruginosa isolates recovered from sputum of cystic fibrosis patients

James D. Finklea; Rita Hollaway; Karen Lowe; Francesca Lee; Jade Le; Raksha Jain

doi:10.1016/j.diagmicrobio.2018.05.002

Ceftolozane/tazobactam sensitivity patterns in Pseudomonas aeruginosa isolates recovered from sputum of cystic fibrosis patients

James D. Finklea, Rita Hollaway, Karen Lowe, Francesca Lee, Jade Le, Raksha Jain

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Ceftolozane/tazobactam is a combination intravenous antibiotic with potentially important activity against drug-resistant Gram-negative organisms. Ceftolozane/tazobactam's in vitro activity was evaluated in 30 samples collected from 23 adult cystic fibrosis patients with extended and pan-resistant Pseudomonas aeruginosa in 2015. Testing results demonstrated that 30% of the isolates were susceptible,13% were intermediate, and 57% were resistant. This suggests that ceftolozane/tazobactam may be a useful antibiotic in carefully selected, multidrug-resistant Pseudomonas isolates.

Original language	English (US)
Journal	Diagnostic Microbiology and Infectious Disease
DOIs	https://doi.org/10.1016/j.diagmicrobio.2018.05.002
State	Accepted/In press - Jan 1 2018

Keywords

Antibiotic
beta-Lactam
Cystic fibrosis
Pseudomonas
Susceptibility

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1016/j.diagmicrobio.2018.05.002

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title = "Ceftolozane/tazobactam sensitivity patterns in Pseudomonas aeruginosa isolates recovered from sputum of cystic fibrosis patients",

abstract = "Ceftolozane/tazobactam is a combination intravenous antibiotic with potentially important activity against drug-resistant Gram-negative organisms. Ceftolozane/tazobactam's in vitro activity was evaluated in 30 samples collected from 23 adult cystic fibrosis patients with extended and pan-resistant Pseudomonas aeruginosa in 2015. Testing results demonstrated that 30% of the isolates were susceptible,13% were intermediate, and 57% were resistant. This suggests that ceftolozane/tazobactam may be a useful antibiotic in carefully selected, multidrug-resistant Pseudomonas isolates.",

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T1 - Ceftolozane/tazobactam sensitivity patterns in Pseudomonas aeruginosa isolates recovered from sputum of cystic fibrosis patients

AU - Finklea, James D.

AU - Hollaway, Rita

AU - Lowe, Karen

AU - Lee, Francesca

AU - Le, Jade

AU - Jain, Raksha

PY - 2018/1/1

Y1 - 2018/1/1

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AB - Ceftolozane/tazobactam is a combination intravenous antibiotic with potentially important activity against drug-resistant Gram-negative organisms. Ceftolozane/tazobactam's in vitro activity was evaluated in 30 samples collected from 23 adult cystic fibrosis patients with extended and pan-resistant Pseudomonas aeruginosa in 2015. Testing results demonstrated that 30% of the isolates were susceptible,13% were intermediate, and 57% were resistant. This suggests that ceftolozane/tazobactam may be a useful antibiotic in carefully selected, multidrug-resistant Pseudomonas isolates.

KW - Antibiotic

KW - beta-Lactam

KW - Cystic fibrosis

KW - Pseudomonas

KW - Susceptibility

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Ceftolozane/tazobactam sensitivity patterns in Pseudomonas aeruginosa isolates recovered from sputum of cystic fibrosis patients

Abstract

Keywords

ASJC Scopus subject areas

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