@article{2c5a56c3c69448f2a6618b354be95b2f,
title = "C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling",
abstract = "The heart has the ability to grow in size in response to exercise, but little is known about the transcriptional mechanisms underlying physiological hypertrophy. Adult cardiomyocytes have also recently been proven to hold the potential for proliferation, a process that could be of great importance for regenerative medicine. Using a unique RT-PCR-based screen against all transcriptional components, we showed that C/EBPβ was downregulated with exercise, whereas the expression of CITED4 was increased. Reduction of C/EBPβ in vitro and in vivo resulted in a phenocopy of endurance exercise with cardiomyocyte hypertrophy and proliferation. This proliferation was mediated, at least in part, by the increased CITED4. Importantly, mice with reduced cardiac C/EBPβ levels displayed substantial resistance to cardiac failure upon pressure overload. These data indicate that C/EBPβ represses cardiomyocyte growth and proliferation in the adult mammalian heart and that reduction in C/EBPβ is a central signal in physiologic hypertrophy and proliferation. PaperClip:",
author = "Pontus Bostr{\"o}m and Nina Mann and Jun Wu and Quintero, {Pablo A.} and Plovie, {Eva R.} and Daniela Pan{\'a}kov{\'a} and Gupta, {Rana K.} and Chunyang Xiao and MacRae, {Calum A.} and Anthony Rosenzweig and Spiegelman, {Bruce M.}",
note = "Funding Information: We thank Shingo Kajimura for valuable discussion during the progression of the manuscript. This project was supported by NIH grant R01 HL085593. P.B. was supported by the Swedish Heart and Lung foundation, SSMF, and the Wenner-Gren Foundation. J.W. was supported by a postdoctoral fellowship from the American Heart Association (Founders Affiliate #09POST2010078). N.M. is a trainee the Harvard/MIT Health Sciences and Technology Program and is supported by a Howard Hughes Postdoctoral Fellowship. P.A.Q. is supported by a T32 training grant. This research was supported in part by a Leducq Foundation Network of Research Excellence (B.M.S. and A.R.) and grants from the NIH (A.R. and B.W.S.). A.R. also gratefully acknowledges support from Judith and David Ganz and the Maxwell Hurston Charitable Foundation. A.R. is a principal faculty member of the Harvard Stem Cell Institute. ",
year = "2010",
month = dec,
day = "23",
doi = "10.1016/j.cell.2010.11.036",
language = "English (US)",
volume = "143",
pages = "1072--1083",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "7",
}