Cdk5 and the mystery of synaptic vesicle endocytosis

Chan Nguyen, James A. Bibb

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations


Regulation of endocytosis by protein phosphorylation and dephosphorylation is critical to synaptic vesicle recycling. Two groups have now identified the neuronal kinase Cdk5 (cyclin-dependent kinase 5) as an important regulator of this process. Robinson and coworkers recently demonstrated that Cdk5 is necessary for synaptic vesicle endocytosis (SVE) (Tan et al., 2003), whereas a new report in this issue claims that Cdk5 negatively regulates SVE (Tomizawa et al., 2003). Careful examination of the data reveals a model that helps resolve the apparently contradictory nature of these reports.

Original languageEnglish (US)
Pages (from-to)697-699
Number of pages3
JournalJournal of Cell Biology
Issue number4
StatePublished - Nov 24 2003

ASJC Scopus subject areas

  • Cell Biology


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