CDK1/2/5 blockade: killing two birds with one stone

Jiao Liu; Rui Kang; Daolin Tang

doi:10.1080/2162402X.2021.1875612

CDK1/2/5 blockade: killing two birds with one stone

Jiao Liu, Rui Kang, Daolin Tang

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is an immune resistant tumor. We recently demonstrated that inhibiting CDK1/2/5 by dinaciclib not only blocks immune checkpoint expression, but also triggers histone-dependent immunogenic cell death. This dual mechanism turns immunologically “cold” tumor microenvironment into a “hot” one, improves overall survival rates in mouse PDAC models.

Original language	English (US)
Article number	1875612
Journal	OncoImmunology
Volume	10
Issue number	1
DOIs	https://doi.org/10.1080/2162402X.2021.1875612
State	Published - 2021

Keywords

Apoptosis
CDK
dinaciclib
histone
immune checkpoint
immunogenic cell death
immunotherapy
pancreatic cancer

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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10.1080/2162402X.2021.1875612

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title = "CDK1/2/5 blockade: killing two birds with one stone",

abstract = "Pancreatic ductal adenocarcinoma (PDAC) is an immune resistant tumor. We recently demonstrated that inhibiting CDK1/2/5 by dinaciclib not only blocks immune checkpoint expression, but also triggers histone-dependent immunogenic cell death. This dual mechanism turns immunologically “cold” tumor microenvironment into a “hot” one, improves overall survival rates in mouse PDAC models.",

keywords = "Apoptosis, CDK, dinaciclib, histone, immune checkpoint, immunogenic cell death, immunotherapy, pancreatic cancer",

author = "Jiao Liu and Rui Kang and Daolin Tang",

note = "Publisher Copyright: {\textcopyright} 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.",

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AU - Kang, Rui

AU - Tang, Daolin

PY - 2021

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AB - Pancreatic ductal adenocarcinoma (PDAC) is an immune resistant tumor. We recently demonstrated that inhibiting CDK1/2/5 by dinaciclib not only blocks immune checkpoint expression, but also triggers histone-dependent immunogenic cell death. This dual mechanism turns immunologically “cold” tumor microenvironment into a “hot” one, improves overall survival rates in mouse PDAC models.

KW - Apoptosis

KW - CDK

KW - dinaciclib

KW - histone

KW - immune checkpoint

KW - immunogenic cell death

KW - immunotherapy

KW - pancreatic cancer

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ER -

CDK1/2/5 blockade: killing two birds with one stone

Abstract

Keywords

ASJC Scopus subject areas

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