@article{21abfbdb937947a98a019b4c1f156f29,
title = "CD99 is a therapeutic target on disease stem cells in myeloid malignancies",
abstract = "Acute myeloid leukemia (AML) and the myelodysplastic syndromes (MDS) are initiated and sustained by selfrenewing malignant stem cells; thus, eradication of AML and MDS stem cells is required for cure. We identified CD99 as a cell surface protein frequently overexpressed on AML and MDS stem cells. Expression of CD99 allows for prospective separation of leukemic stem cells (LSCs) from functionally normal hematopoietic stem cells in AML, and high CD99 expression on AML blasts enriches for functional LSCs as demonstrated by limiting dilution xenotransplant studies. Monoclonal antibodies (mAbs) targeting CD99 induce the death of AML and MDS cells in a SARC family kinase-dependent manner in the absence of immune effector cells or complement, and anti- CD99 mAbs exhibit antileukemic activity in AML xenografts. These data establish CD99 as a marker of AML and MDS stem cells, as well as a promising therapeutic target in these disorders. 2017",
author = "Chung, {Stephen S.} and Eng, {William S.} and Wenhuo Hu and Mona Khalaj and Garrett-Bakelman, {Francine E.} and Montreh Tavakkoli and Levine, {Ross L.} and Martin Carroll and Klimek, {Virginia M.} and Melnick, {Ari M.} and Park, {Christopher Y.}",
note = "Funding Information: This work was supported by a Young Investigator Award from the Conquer Cancer Foundation of the American Society of Clinical Oncology, a U.S. Department of Defense Postdoctoral Fellow Award in Bone Marrow Failure Research (BM120096), and a Fellow Scholar Award from the American Society of Hematology (all to S.S.C.), as well as a Clinical Scientist Award from the Doris Duke Charitable Foundation, a Translational Research Program Award from the Leukemia and Lymphoma Society, and a Geoffrey Beene Grant from the Geoffrey Beene Cancer Research Center (all to C.Y.P.). Publisher Copyright: {\textcopyright} The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science.",
year = "2017",
month = jan,
day = "25",
doi = "10.1126/scitranslmed.aaj2025",
language = "English (US)",
volume = "9",
journal = "Science translational medicine",
issn = "1946-6234",
publisher = "American Association for the Advancement of Science",
number = "374",
}