CD8+ T cell help is required for efficient induction of EAE in Lewis rats

Monika Camara; Niklas Beyersdorf; Henrike J. Fischer; Marco J. Herold; Chi Wang Ip; Jens van den Brandt; Klaus V. Toyka; Joel D. Taurog; Thomas Hünig; Thomas Herrmann; Holger M. Reichardt; Andreas Weishaupt; Thomas Kerkau

doi:10.1016/j.jneuroim.2013.04.014

CD8⁺ T cell help is required for efficient induction of EAE in Lewis rats

Monika Camara, Niklas Beyersdorf, Henrike J. Fischer, Marco J. Herold, Chi Wang Ip, Jens van den Brandt, Klaus V. Toyka, Joel D. Taurog, Thomas Hünig, Thomas Herrmann, Holger M. Reichardt, Andreas Weishaupt, Thomas Kerkau

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The role of CD8⁺ T cells in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) is still unclear. We describe here significantly reduced disease activity of EAE both in Lewis rats depleted of CD8⁺ T cells by monoclonal antibodies and CD8 knockout rats, which was accompanied by reduced leukocyte infiltration into the spinal cord. We detected myelin basic protein (MBP)-specific CD4⁺ T cells in peripheral lymphoid organs of CD8-depleted animals which, however, failed to differentiate into interferon-γ-producing effector cells. Our results indicate that CD8⁺ T cells interact with myelin-specific CD4⁺ T cells early in EAE enabling them to differentiate into pathogenic effector cells.

Original language	English (US)
Pages (from-to)	17-27
Number of pages	11
Journal	Journal of Neuroimmunology
Volume	260
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2013.04.014
State	Published - 2013

Keywords

CD8 T cell
Experimental autoimmune encephalomyelitis
Multiple sclerosis

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

Access to Document

10.1016/j.jneuroim.2013.04.014

Cite this

@article{9233c7951ae142fba98d5ee75656bc40,

title = "CD8+ T cell help is required for efficient induction of EAE in Lewis rats",

abstract = "The role of CD8+ T cells in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) is still unclear. We describe here significantly reduced disease activity of EAE both in Lewis rats depleted of CD8+ T cells by monoclonal antibodies and CD8 knockout rats, which was accompanied by reduced leukocyte infiltration into the spinal cord. We detected myelin basic protein (MBP)-specific CD4+ T cells in peripheral lymphoid organs of CD8-depleted animals which, however, failed to differentiate into interferon-γ-producing effector cells. Our results indicate that CD8+ T cells interact with myelin-specific CD4+ T cells early in EAE enabling them to differentiate into pathogenic effector cells.",

keywords = "CD8 T cell, Experimental autoimmune encephalomyelitis, Multiple sclerosis",

author = "Monika Camara and Niklas Beyersdorf and Fischer, {Henrike J.} and Herold, {Marco J.} and Ip, {Chi Wang} and {van den Brandt}, Jens and Toyka, {Klaus V.} and Taurog, {Joel D.} and Thomas H{\"u}nig and Thomas Herrmann and Reichardt, {Holger M.} and Andreas Weishaupt and Thomas Kerkau",

note = "Funding Information: This work was supported by the Deutsche Forschungsgemeinschaft through grant SFB/TRR (project B13) and by a grant from the Interdisziplin{\"a}res Zentrum f{\"u}r klinische Forschung W{\"u}rzburg ( IZKF A-52 ). ",

year = "2013",

doi = "10.1016/j.jneuroim.2013.04.014",

language = "English (US)",

volume = "260",

pages = "17--27",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - CD8+ T cell help is required for efficient induction of EAE in Lewis rats

AU - Camara, Monika

AU - Beyersdorf, Niklas

AU - Fischer, Henrike J.

AU - Herold, Marco J.

AU - Ip, Chi Wang

AU - van den Brandt, Jens

AU - Toyka, Klaus V.

AU - Taurog, Joel D.

AU - Hünig, Thomas

AU - Herrmann, Thomas

AU - Reichardt, Holger M.

AU - Weishaupt, Andreas

AU - Kerkau, Thomas

N1 - Funding Information: This work was supported by the Deutsche Forschungsgemeinschaft through grant SFB/TRR (project B13) and by a grant from the Interdisziplinäres Zentrum für klinische Forschung Würzburg ( IZKF A-52 ).

PY - 2013

Y1 - 2013

N2 - The role of CD8+ T cells in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) is still unclear. We describe here significantly reduced disease activity of EAE both in Lewis rats depleted of CD8+ T cells by monoclonal antibodies and CD8 knockout rats, which was accompanied by reduced leukocyte infiltration into the spinal cord. We detected myelin basic protein (MBP)-specific CD4+ T cells in peripheral lymphoid organs of CD8-depleted animals which, however, failed to differentiate into interferon-γ-producing effector cells. Our results indicate that CD8+ T cells interact with myelin-specific CD4+ T cells early in EAE enabling them to differentiate into pathogenic effector cells.

AB - The role of CD8+ T cells in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) is still unclear. We describe here significantly reduced disease activity of EAE both in Lewis rats depleted of CD8+ T cells by monoclonal antibodies and CD8 knockout rats, which was accompanied by reduced leukocyte infiltration into the spinal cord. We detected myelin basic protein (MBP)-specific CD4+ T cells in peripheral lymphoid organs of CD8-depleted animals which, however, failed to differentiate into interferon-γ-producing effector cells. Our results indicate that CD8+ T cells interact with myelin-specific CD4+ T cells early in EAE enabling them to differentiate into pathogenic effector cells.

KW - CD8 T cell

KW - Experimental autoimmune encephalomyelitis

KW - Multiple sclerosis

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