Cbl-b and itch: Key regulators of peripheral T-cell tolerance

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations


E3 ligases Cbl-b and Itch have emerged as dominant "tolerogenic" regulators of T cells because their deficiency results in severe autoimmune diseases. Cbl-b and Itch ligase activity regulate T-cell anergy and development of Foxp3+ regulatory T cells (Treg) in the periphery by modulating key components of T-cell receptor (TCR) and transforming growth factor-β (TGF-β) signaling. Manipulation of Cbl-b and Itch activities may provide unique opportunities to develop future therapies for immune disorders such as autoimmunity and cancer.

Original languageEnglish (US)
Pages (from-to)3009-3012
Number of pages4
JournalCancer research
Issue number8
StatePublished - Apr 15 2010
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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