TY - JOUR
T1 - Caveolins and caveolae in ocular physiology and pathophysiology
AU - Gu, Xiaowu
AU - Reagan, Alaina M.
AU - McClellan, Mark E.
AU - Elliott, Michael H.
N1 - Funding Information:
The work from the Elliott laboratory presented herein was funded in part by NIH grants R01-EY019494, P30-EY021725 (Core Grant, OUHSC), T32-EY023202 (Training Grant, OUHSC) the BrightFocus Foundation grant G2013092, the Alcon Research Institute, Sybil B. Harrington Special Scholar Award for Macular Degeneration Research and by an unrestricted grant to the OUHSC Department of Ophthalmology from Research to Prevent Blindness, Inc. The authors wish to thank the laboratories of several current and former collaborators including Drs. Steven Fliesler, Silvia Finnemann, Dan Stamer, Ernst Tamm, Masaki Tanito, Timothy Lyons, Gene Anderson, Daniel Carr, Michelle Callegan, Nawajes Mandal, Bill Stallcup, You-Yang Zhao, Richard Minshall, Yun Le, and Timothy Thompson. We also thank Dr. Simon John for kindly sharing unpublished data on IOP and outflow facility from Cav-1
Publisher Copyright:
© 2016 Elsevier Ltd
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Caveolae are specialized, invaginated plasma membrane domains that are defined morphologically and by the expression of signature proteins called, caveolins. Caveolae and caveolins are abundant in a variety of cell types including vascular endothelium, glia, and fibroblasts where they play critical roles in transcellular transport, endocytosis, mechanotransduction, cell proliferation, membrane lipid homeostasis, and signal transduction. Given these critical cellular functions, it is surprising that ablation of the caveolae organelle does not result in lethality suggesting instead that caveolae and caveolins play modulatory roles in cellular homeostasis. Caveolar components are also expressed in ocular cell types including retinal vascular cells, Müller glia, retinal pigment epithelium (RPE), conventional aqueous humor outflow cells, the corneal epithelium and endothelium, and the lens epithelium. In the eye, studies of caveolae and other membrane microdomains (i.e., “lipid rafts”) have lagged behind what is a substantial body of literature outside vision science. However, interest in caveolae and their molecular components has increased with accumulating evidence of important roles in vision-related functions such as blood-retinal barrier homeostasis, ocular inflammatory signaling, pathogen entry at the ocular surface, and aqueous humor drainage. The recent association of CAV1/2 gene loci with primary open angle glaucoma and intraocular pressure has further enhanced the need to better understand caveolar functions in the context of ocular physiology and disease. Herein, we provide the first comprehensive review of literature on caveolae, caveolins, and other membrane domains in the context of visual system function. This review highlights the importance of caveolae domains and their components in ocular physiology and pathophysiology and emphasizes the need to better understand these important modulators of cellular function.
AB - Caveolae are specialized, invaginated plasma membrane domains that are defined morphologically and by the expression of signature proteins called, caveolins. Caveolae and caveolins are abundant in a variety of cell types including vascular endothelium, glia, and fibroblasts where they play critical roles in transcellular transport, endocytosis, mechanotransduction, cell proliferation, membrane lipid homeostasis, and signal transduction. Given these critical cellular functions, it is surprising that ablation of the caveolae organelle does not result in lethality suggesting instead that caveolae and caveolins play modulatory roles in cellular homeostasis. Caveolar components are also expressed in ocular cell types including retinal vascular cells, Müller glia, retinal pigment epithelium (RPE), conventional aqueous humor outflow cells, the corneal epithelium and endothelium, and the lens epithelium. In the eye, studies of caveolae and other membrane microdomains (i.e., “lipid rafts”) have lagged behind what is a substantial body of literature outside vision science. However, interest in caveolae and their molecular components has increased with accumulating evidence of important roles in vision-related functions such as blood-retinal barrier homeostasis, ocular inflammatory signaling, pathogen entry at the ocular surface, and aqueous humor drainage. The recent association of CAV1/2 gene loci with primary open angle glaucoma and intraocular pressure has further enhanced the need to better understand caveolar functions in the context of ocular physiology and disease. Herein, we provide the first comprehensive review of literature on caveolae, caveolins, and other membrane domains in the context of visual system function. This review highlights the importance of caveolae domains and their components in ocular physiology and pathophysiology and emphasizes the need to better understand these important modulators of cellular function.
KW - Blood-retinal barrier
KW - Caveolae
KW - Caveolin
KW - Glaucoma
KW - Lipid rafts
KW - Neuroinflammation
KW - Ocular hypertension
KW - Vascular permeability
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U2 - 10.1016/j.preteyeres.2016.09.005
DO - 10.1016/j.preteyeres.2016.09.005
M3 - Review article
C2 - 27664379
AN - SCOPUS:85005993277
SN - 1350-9462
VL - 56
SP - 84
EP - 106
JO - Progress in Retinal and Eye Research
JF - Progress in Retinal and Eye Research
ER -