Abstract
Competition under control: A practical and efficient direct asymmetric vinylogous Michael reaction of deconjugated butenolides has been developed (see scheme). The products of this reaction, highly functionalized chiral succinimides, are obtained in excellent yield with high diastereoselectivity (up to d.r.=18:1) and outstanding enantioselectivity (up to e.r.=99.5:0.5).
Original language | English (US) |
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Pages (from-to) | 15277-15282 |
Number of pages | 6 |
Journal | Chemistry - A European Journal |
Volume | 18 |
Issue number | 48 |
DOIs | |
State | Published - Nov 26 2012 |
Externally published | Yes |
Keywords
- Michael addition
- asymmetric catalysis
- butyrolactone
- maleimide
- thiourea
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry