Cas adaptor proteins organize the retinal ganglion cell layer downstream of integrin signaling

Martin M. Riccomagno, Lu O. Sun, Colleen M. Brady, Konstantina Alexandropoulos, Sachiko Seo, Mineo Kurokawa, Alex L. Kolodkin

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Stratification of retinal neuronal cell bodies and lamination of their processes provide a scaffold upon which neural circuits can be built. However, the molecular mechanisms that direct retinal ganglion cells (RGCs) to resolve into a single-cell retinal ganglioncell layer (GCL) are not well understood. The extracellular matrix protein laminin conveys spatial information that instructs the migration, process outgrowth, and reorganization of GCL cells. Here, we show that the β1-Integrin laminin receptor is required for RGC positioning and reorganization into a single-cell GCL layer. β1-Integrin signaling within migrating GCL cells requires Cas signaling-adaptor proteins, and in the absence of β1-Integrin or Cas function retinal neurons form ectopic cell clusters beyond the inner-limiting membrane (ILM), phenocopying laminin mutants. These data reveal an essential role for Cas adaptor proteins in β1-Integrin-mediated signaling events critical for the formation of the single-cell GCL in the mammalian retina.

Original languageEnglish (US)
Pages (from-to)779-786
Number of pages8
Issue number4
StatePublished - Feb 19 2014
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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