Carpatamides A-C, cytotoxic arylamine derivatives from a marine-derived streptomyces sp.

Peng Fu; Melissa Johnson; Hong Chen; Bruce A. Posner; John B. MacMillan

doi:10.1021/np500207p

Carpatamides A-C, cytotoxic arylamine derivatives from a marine-derived streptomyces sp.

Peng Fu, Melissa Johnson, Hong Chen, Bruce A. Posner, John B. MacMillan

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Three new acylated arylamine derivatives (1-3), carpatamides A-C, were isolated from a marine-derived Streptomyces sp. based on activity screening against non-small-cell lung cancer (NSCLC). The structures of 1-3 were established on the basis of comprehensive spectroscopic analyses and chemical methods. Compounds 1 and 3 showed moderate cytotoxicity against NSCLC cell lines HCC366, A549, and HCC44 with IC₅₀ values ranging from 2.2 to 8.4 μM.

Original language	English (US)
Pages (from-to)	1245-1248
Number of pages	4
Journal	Journal of Natural Products
Volume	77
Issue number	5
DOIs	https://doi.org/10.1021/np500207p
State	Published - May 23 2014

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

Access to Document

10.1021/np500207p

Cite this

@article{4206042e92ef4cbfad7bbb3424d8ef36,

title = "Carpatamides A-C, cytotoxic arylamine derivatives from a marine-derived streptomyces sp.",

abstract = "Three new acylated arylamine derivatives (1-3), carpatamides A-C, were isolated from a marine-derived Streptomyces sp. based on activity screening against non-small-cell lung cancer (NSCLC). The structures of 1-3 were established on the basis of comprehensive spectroscopic analyses and chemical methods. Compounds 1 and 3 showed moderate cytotoxicity against NSCLC cell lines HCC366, A549, and HCC44 with IC50 values ranging from 2.2 to 8.4 μM.",

author = "Peng Fu and Melissa Johnson and Hong Chen and Posner, {Bruce A.} and MacMillan, {John B.}",

year = "2014",

month = may,

day = "23",

doi = "10.1021/np500207p",

language = "English (US)",

volume = "77",

pages = "1245--1248",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "5",

}

TY - JOUR

T1 - Carpatamides A-C, cytotoxic arylamine derivatives from a marine-derived streptomyces sp.

AU - Fu, Peng

AU - Johnson, Melissa

AU - Chen, Hong

AU - Posner, Bruce A.

AU - MacMillan, John B.

PY - 2014/5/23

Y1 - 2014/5/23

N2 - Three new acylated arylamine derivatives (1-3), carpatamides A-C, were isolated from a marine-derived Streptomyces sp. based on activity screening against non-small-cell lung cancer (NSCLC). The structures of 1-3 were established on the basis of comprehensive spectroscopic analyses and chemical methods. Compounds 1 and 3 showed moderate cytotoxicity against NSCLC cell lines HCC366, A549, and HCC44 with IC50 values ranging from 2.2 to 8.4 μM.

AB - Three new acylated arylamine derivatives (1-3), carpatamides A-C, were isolated from a marine-derived Streptomyces sp. based on activity screening against non-small-cell lung cancer (NSCLC). The structures of 1-3 were established on the basis of comprehensive spectroscopic analyses and chemical methods. Compounds 1 and 3 showed moderate cytotoxicity against NSCLC cell lines HCC366, A549, and HCC44 with IC50 values ranging from 2.2 to 8.4 μM.

UR - http://www.scopus.com/inward/record.url?scp=84901675721&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901675721&partnerID=8YFLogxK

U2 - 10.1021/np500207p

DO - 10.1021/np500207p

M3 - Article

C2 - 24754815

AN - SCOPUS:84901675721

SN - 0163-3864

VL - 77

SP - 1245

EP - 1248

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 5

ER -

Carpatamides A-C, cytotoxic arylamine derivatives from a marine-derived streptomyces sp.

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this