TY - JOUR
T1 - Carisoprodol-induced myoclonic encephalopathy
AU - Roth, Brett A.
AU - Vinson, David R.
AU - Kim, Susan
PY - 1998
Y1 - 1998
N2 - Case Report: A 39-year-old man ingested 35 g carisoprodol. He developed agitation, tachycardia, myoclonus, and coma. The blood carisoprodol was 71 μg/mL; the meprobamate was 26 μg/mL. Discussion: Carisoprodol overdose is thought to induce simple central nervous system depression. This case demonstrates a severe overdose with symptoms more consistent with myoclonic encephalopathy. A review of cases presenting to the San Francisco Division of the California Poison Control System during 1997 suggests that carisoprodol is more commonly associated with agitation and bizarre movement disorders than the current literature suggests. The pharmacology and potential mechanisms of toxicity are discussed. Conclusion: Agitation, hypertonia, and a myoclonic encephalopathy may be seen with significant carisoprodol intoxication.
AB - Case Report: A 39-year-old man ingested 35 g carisoprodol. He developed agitation, tachycardia, myoclonus, and coma. The blood carisoprodol was 71 μg/mL; the meprobamate was 26 μg/mL. Discussion: Carisoprodol overdose is thought to induce simple central nervous system depression. This case demonstrates a severe overdose with symptoms more consistent with myoclonic encephalopathy. A review of cases presenting to the San Francisco Division of the California Poison Control System during 1997 suggests that carisoprodol is more commonly associated with agitation and bizarre movement disorders than the current literature suggests. The pharmacology and potential mechanisms of toxicity are discussed. Conclusion: Agitation, hypertonia, and a myoclonic encephalopathy may be seen with significant carisoprodol intoxication.
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U2 - 10.3109/15563659809028058
DO - 10.3109/15563659809028058
M3 - Article
C2 - 9776967
AN - SCOPUS:0031688156
SN - 0731-3810
VL - 36
SP - 609
EP - 612
JO - Journal of Toxicology - Clinical Toxicology
JF - Journal of Toxicology - Clinical Toxicology
IS - 6
ER -