Cardiovascular health and dementia incidence among older adults in Latin America: Results from the 10/66 study

Jaime Perales-Puchalt, Michelle L. Vidoni, Juan Llibre Rodríguez, Eric D. Vidoni, Sandra Billinger, Jeffrey Burns, Maëlenn Guerchet, Min Jae Lee

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Objectives: Growing evidence shows that cardiovascular health (CVH) is associated with brain health. Little is known about this topic among older adults in Latin America, where the number of people living with dementia is rising. This study aimed to assess the longitudinal association between CVH and dementia in six Latin American countries. Methods: We analyzed longitudinal data from the 10/66 study that included nondementia residents at baseline aged 65+ in six Latin American countries (n = 6447) and were followed up for 3 years. An index of modifiable CVH factors (ranging from 0 to 14) was calculated. Incident dementia was modeled using competing risk regression to adjust for risk of death. Results: The sample included 6.2% participants with poor (0-5), 81.0% with moderate (6-10), and 12.8% with ideal CVH (11-14). At follow-up, 9.4% had developed dementia and 13.1% had died. Compared with those with poor CVH, participants with moderate and ideal levels of CVH had a significantly lower risk of dementia in both the unadjusted (subhazard ratio for moderate, 0.77; ideal, 0.59) and adjusted models (moderate, 0.73; ideal, 0.66). Conclusion: Moderate and ideal levels of CVH in old age may protect against dementia incidence. These findings may inform health promotion efforts within dementia national plans adopted recently in some Latin American countries.

Original languageEnglish (US)
Pages (from-to)1041-1049
Number of pages9
JournalInternational Journal of Geriatric Psychiatry
Issue number7
StatePublished - Jul 2019
Externally publishedYes


  • Latin America
  • cardiovascular health
  • competing risks
  • dementia
  • survival analysis

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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