Cardiac plasticity

Research output: Contribution to journalReview articlepeer-review

898 Scopus citations


This review explains how the heart responds to physiologic or pathologic conditions. Exercise, pregnancy, and postnatal growth cause physiologic growth; neurohumoral activation, hypertension, and myocardial injury cause hypertrophic growth, which increases the risk of heart failure and malignant arrhythmia. Atrophy of the heart can arise from protracted bed rest, prolonged weightlessness, or mechanical unloading with a ventricular assist device.

Original languageEnglish (US)
Pages (from-to)1370
Number of pages1
JournalNew England Journal of Medicine
Issue number13
StatePublished - Mar 27 2008

ASJC Scopus subject areas

  • Medicine(all)


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