Cancer Immune Checkpoint Inhibitor Therapy and the Gut Microbiota

Arthur E. Frankel, Sachin Deshmukh, Amit Reddy, John Lightcap, Maureen Hayes, Steven McClellan, Seema Singh, Brooks Rabideau, T. Grant Glover, Bruce Roberts, Andrew Y. Koh

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations


The past decade has seen tremendous advances in both our understanding of cancer immunosuppressive microenvironments and colonic bacteria facilitated by immune checkpoint inhibitor antibodies and next generation sequencing, respectively. Because an important role of the host immune system is to communicate with and regulate the gut microbial community, it should not come as a surprise that the behavior of one is coupled to the other. In this review, we will attempt to dissect some of the studies demonstrating cancer immunotherapy modulation by specific gut microbes and discuss possible molecular mechanisms for this effect.

Original languageEnglish (US)
JournalIntegrative Cancer Therapies
StatePublished - Apr 1 2019


  • cancer
  • cytotoxic T-lymphocytes
  • dendritic cells
  • gut microbiota
  • immune checkpoint inhibitor therapy

ASJC Scopus subject areas

  • Oncology
  • Complementary and alternative medicine


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