Cancer Immune Checkpoint Inhibitor Therapy and the Gut Microbiota

Arthur E. Frankel; Sachin Deshmukh; Amit Reddy; John Lightcap; Maureen Hayes; Steven McClellan; Seema Singh; Brooks Rabideau; T. Grant Glover; Bruce Roberts; Andrew Y. Koh

doi:10.1177/1534735419846379

Cancer Immune Checkpoint Inhibitor Therapy and the Gut Microbiota

Arthur E. Frankel, Sachin Deshmukh, Amit Reddy, John Lightcap, Maureen Hayes, Steven McClellan, Seema Singh, Brooks Rabideau, T. Grant Glover, Bruce Roberts, Andrew Y. Koh

Research output: Contribution to journal › Review article › peer-review

44 Scopus citations

Abstract

The past decade has seen tremendous advances in both our understanding of cancer immunosuppressive microenvironments and colonic bacteria facilitated by immune checkpoint inhibitor antibodies and next generation sequencing, respectively. Because an important role of the host immune system is to communicate with and regulate the gut microbial community, it should not come as a surprise that the behavior of one is coupled to the other. In this review, we will attempt to dissect some of the studies demonstrating cancer immunotherapy modulation by specific gut microbes and discuss possible molecular mechanisms for this effect.

Original language	English (US)
Journal	Integrative Cancer Therapies
Volume	18
DOIs	https://doi.org/10.1177/1534735419846379
State	Published - Apr 1 2019

Keywords

cancer
cytotoxic T-lymphocytes
dendritic cells
gut microbiota
immune checkpoint inhibitor therapy

ASJC Scopus subject areas

Oncology
Complementary and alternative medicine

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10.1177/1534735419846379

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title = "Cancer Immune Checkpoint Inhibitor Therapy and the Gut Microbiota",

abstract = "The past decade has seen tremendous advances in both our understanding of cancer immunosuppressive microenvironments and colonic bacteria facilitated by immune checkpoint inhibitor antibodies and next generation sequencing, respectively. Because an important role of the host immune system is to communicate with and regulate the gut microbial community, it should not come as a surprise that the behavior of one is coupled to the other. In this review, we will attempt to dissect some of the studies demonstrating cancer immunotherapy modulation by specific gut microbes and discuss possible molecular mechanisms for this effect.",

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AU - Frankel, Arthur E.

AU - Deshmukh, Sachin

AU - Reddy, Amit

AU - Lightcap, John

AU - Hayes, Maureen

AU - McClellan, Steven

AU - Singh, Seema

AU - Rabideau, Brooks

AU - Glover, T. Grant

AU - Roberts, Bruce

AU - Koh, Andrew Y.

N1 - Publisher Copyright: © The Author(s) 2019.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - The past decade has seen tremendous advances in both our understanding of cancer immunosuppressive microenvironments and colonic bacteria facilitated by immune checkpoint inhibitor antibodies and next generation sequencing, respectively. Because an important role of the host immune system is to communicate with and regulate the gut microbial community, it should not come as a surprise that the behavior of one is coupled to the other. In this review, we will attempt to dissect some of the studies demonstrating cancer immunotherapy modulation by specific gut microbes and discuss possible molecular mechanisms for this effect.

AB - The past decade has seen tremendous advances in both our understanding of cancer immunosuppressive microenvironments and colonic bacteria facilitated by immune checkpoint inhibitor antibodies and next generation sequencing, respectively. Because an important role of the host immune system is to communicate with and regulate the gut microbial community, it should not come as a surprise that the behavior of one is coupled to the other. In this review, we will attempt to dissect some of the studies demonstrating cancer immunotherapy modulation by specific gut microbes and discuss possible molecular mechanisms for this effect.

KW - cancer

KW - cytotoxic T-lymphocytes

KW - dendritic cells

KW - gut microbiota

KW - immune checkpoint inhibitor therapy

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JO - Integrative Cancer Therapies

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Cancer Immune Checkpoint Inhibitor Therapy and the Gut Microbiota

Abstract

Keywords

ASJC Scopus subject areas

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