Cancer genetics

J. William Harbour, Daniel L. Chao

Research output: Chapter in Book/Report/Conference proceedingChapter


A fundamental characteristic of cancer cells is their ability to proliferate and survive outside of their normal physiologic context. This ability is acquired through genetic and epigenetic alterations that modify the cell’s interaction with its environment. As such, some of the most common cancer-related genes are involved in cell cycle, differentiation, apoptosis, and angiogenesis. These genes are often referred to as oncogenes and tumor suppressor genes, depending on whether cancer-causing mutations result in gain or loss of function, respectively. Here we will review some of the genes and pathways that commonly are deregulated in cancer.

Original languageEnglish (US)
Title of host publicationClinical Ophthalmic Oncology
Subtitle of host publicationBasic Principles and Diagnostic Techniques, Second Edition
PublisherSpringer Berlin Heidelberg
Number of pages6
ISBN (Electronic)9783642404894
ISBN (Print)9783642404887
StatePublished - Jan 1 2014
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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