Abstract
Dormancy in the murine BCL1 lymphoma can be induced by several strategies including cytoreductive therapy of mice with large tumor burdens and challenge of allogeneic chimeric mice or idiotype-immunized mice with BCL1 tumor. Dormant tumor cells were isolated from the spleens of the chimeric mice and the majority were shown to be noncycling. In idiotype-immunized mice that had lost dormancy, tumor growth occurred at a relatively rapid rate. A proportion of idiotype-immunized mice that had lost dormancy spontaneously regressed and then again relapsed; in these mice, the serum antiidiotypic levels were inversely related to the tumor burden.
Original language | English (US) |
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Pages (from-to) | 5045s-5053s |
Journal | Cancer research |
Volume | 51 |
Issue number | 18 SUPPL. |
State | Published - Sep 15 1991 |
ASJC Scopus subject areas
- Oncology
- Cancer Research