Cancer associated isoenzyme of serum galactosyltransferase

M. M. Weiser, D. K. Podolsky, K. Isselbacher

Research output: Contribution to journalArticlepeer-review

69 Scopus citations


Galactosyltransferase activity was assayed in sera from 58 patients with various types of cancer. On discontinuous polyacrylamide gel electrophoresis a slow moving peak of galactosyltransferase activity (isoenzyme II) was found to be present in the serum of 43 of these patients in addition to the major isoenzyme I. Isoenzyme II was found in only 2 of 39 patients with various nonmalignant disorders and was not detected in the serum of 22 normal control subjects. There was no correlation between the presence of this electrophoretically distinct isoenzyme and total serum galactosyltransferase activity, alkaline phosphatase, levels of carcinoembryonic antigen, or blood type. However, patients with widespread metastases had significantly higher isoenzyme II levels than those with no metastases or with limited local spread. Further studies will be necessary to evaluate the clinical usefulness of this serum galactosyltransferase isoenzyme in the diagnosis and monitoring of patients with neoplastic disease.

Original languageEnglish (US)
Pages (from-to)1319-1322
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number4
StatePublished - 1976

ASJC Scopus subject areas

  • General


Dive into the research topics of 'Cancer associated isoenzyme of serum galactosyltransferase'. Together they form a unique fingerprint.

Cite this