Cancer and blood concentrations of the comutagen harmane in essential tremor

Elan D. Louis; Kathryn M. Pellegrino; Pam Factor-Litvak; Eileen Rios; Wendy Jiang; Claire Henchcliffe; Wei Zheng

doi:10.1002/mds.22084

Cancer and blood concentrations of the comutagen harmane in essential tremor

Elan D. Louis, Kathryn M. Pellegrino, Pam Factor-Litvak, Eileen Rios, Wendy Jiang, Claire Henchcliffe, Wei Zheng

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Blood concentrations of harmane, a tremor-producing neurotoxin, are elevated in essential tremor (ET). Harmane is also a comutagen. Using a case-control design, we compared the prevalence of cancer in ET cases vs. controls, and determined whether blood harmane concentrations are elevated among ET cases with cancer. 66/267 (24.7%) ET cases vs. 55/331 (16.6%) controls had cancer (adjusted OR 1.52, 95% CI 1.01-2.30, P = 0.04). Among specific cancer types, colon cancer was more prevalent in ET cases than controls (2.6% vs. 0.6%, P = 0.04). Log blood harmane concentration was higher in ET cases vs. controls (P = 0.02) and in participants with vs. without cancer (P = 0.02). Log blood harmane concentration was highest in ET cases with cancer when compared with other groups (P = 0.009). These links between cancer and ET and between high blood harmane and cancer in ET deserve further study.

Original language	English (US)
Pages (from-to)	1747-1751
Number of pages	5
Journal	Movement Disorders
Volume	23
Issue number	12
DOIs	https://doi.org/10.1002/mds.22084
State	Published - Sep 15 2008
Externally published	Yes

Keywords

Cancer
Epidemiology
Essential tremor
Harmane
Toxin

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/mds.22084

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title = "Cancer and blood concentrations of the comutagen harmane in essential tremor",

abstract = "Blood concentrations of harmane, a tremor-producing neurotoxin, are elevated in essential tremor (ET). Harmane is also a comutagen. Using a case-control design, we compared the prevalence of cancer in ET cases vs. controls, and determined whether blood harmane concentrations are elevated among ET cases with cancer. 66/267 (24.7%) ET cases vs. 55/331 (16.6%) controls had cancer (adjusted OR 1.52, 95% CI 1.01-2.30, P = 0.04). Among specific cancer types, colon cancer was more prevalent in ET cases than controls (2.6% vs. 0.6%, P = 0.04). Log blood harmane concentration was higher in ET cases vs. controls (P = 0.02) and in participants with vs. without cancer (P = 0.02). Log blood harmane concentration was highest in ET cases with cancer when compared with other groups (P = 0.009). These links between cancer and ET and between high blood harmane and cancer in ET deserve further study.",

keywords = "Cancer, Epidemiology, Essential tremor, Harmane, Toxin",

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AU - Pellegrino, Kathryn M.

AU - Factor-Litvak, Pam

AU - Rios, Eileen

AU - Jiang, Wendy

AU - Henchcliffe, Claire

AU - Zheng, Wei

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N2 - Blood concentrations of harmane, a tremor-producing neurotoxin, are elevated in essential tremor (ET). Harmane is also a comutagen. Using a case-control design, we compared the prevalence of cancer in ET cases vs. controls, and determined whether blood harmane concentrations are elevated among ET cases with cancer. 66/267 (24.7%) ET cases vs. 55/331 (16.6%) controls had cancer (adjusted OR 1.52, 95% CI 1.01-2.30, P = 0.04). Among specific cancer types, colon cancer was more prevalent in ET cases than controls (2.6% vs. 0.6%, P = 0.04). Log blood harmane concentration was higher in ET cases vs. controls (P = 0.02) and in participants with vs. without cancer (P = 0.02). Log blood harmane concentration was highest in ET cases with cancer when compared with other groups (P = 0.009). These links between cancer and ET and between high blood harmane and cancer in ET deserve further study.

AB - Blood concentrations of harmane, a tremor-producing neurotoxin, are elevated in essential tremor (ET). Harmane is also a comutagen. Using a case-control design, we compared the prevalence of cancer in ET cases vs. controls, and determined whether blood harmane concentrations are elevated among ET cases with cancer. 66/267 (24.7%) ET cases vs. 55/331 (16.6%) controls had cancer (adjusted OR 1.52, 95% CI 1.01-2.30, P = 0.04). Among specific cancer types, colon cancer was more prevalent in ET cases than controls (2.6% vs. 0.6%, P = 0.04). Log blood harmane concentration was higher in ET cases vs. controls (P = 0.02) and in participants with vs. without cancer (P = 0.02). Log blood harmane concentration was highest in ET cases with cancer when compared with other groups (P = 0.009). These links between cancer and ET and between high blood harmane and cancer in ET deserve further study.

KW - Cancer

KW - Epidemiology

KW - Essential tremor

KW - Harmane

KW - Toxin

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Cancer and blood concentrations of the comutagen harmane in essential tremor

Abstract

Keywords

ASJC Scopus subject areas

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