Calorie Restriction in Humans: Impact on Human Health

Eric Ravussin, L. Anne Gilmore, Leanne M. Redman

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations


Calorie restriction, without malnutrition, has been shown to increase longevity and delay the onset of chronic disease in various species. In this chapter, we review the different modalities which scientists and individuals have followed to achieve a sustained caloric deficit. These include traditional dietary restriction regimens of varying degrees, physical activity, alternate day fasting, and alternate day modified fasting. To evaluate the impact of these interventions on chronic disease risk and longevity, we critically evaluate the existing evidence concerning the physiological as well as the behavioral alterations induced by these interventions.

Original languageEnglish (US)
Title of host publicationMolecular Basis of Nutrition and Aging
Subtitle of host publicationA Volume in the Molecular Nutrition Series
PublisherElsevier Inc.
Number of pages16
ISBN (Electronic)9780128018279
ISBN (Print)9780128018163
StatePublished - Apr 28 2016
Externally publishedYes


  • Aging
  • Calorie restriction
  • Hormones
  • Longevity
  • Metabolism
  • Physical activity
  • Quality of life
  • Weight loss

ASJC Scopus subject areas

  • Medicine(all)


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