TY - JOUR
T1 - Calmodulin-driven nuclear entry
T2 - Trigger for sex determination and terminal differentiation
AU - Hanover, John A.
AU - Love, Dona C.
AU - Prinz, William A.
PY - 2009/5/8
Y1 - 2009/5/8
N2 - We originally proposed that Ca2+-calmodulin mediates a novel nuclear entry pathway distinct from the canonic Ran-dependent pathway (Sweitzer, T. D., and Hanover, J. A. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 14574-14579). Although seemingly redundant, Ca2+-calmodulin-driven nuclear entry is now known to facilitate nuclear delivery of architectural transcription factors to chromatin. Intriguingly, defects in calmodulin-driven nuclear import of the transcription factors SRY and SOX9 in Sertoli cells lead to human sex reversal diseases with altered male gonad development. Calmodulin-triggered nuclear entry is an evolutionarily ancient feature of eukaryotes observed from yeast to man. Ca2+-calmodulin-triggered nuclear entry of key architectural transcription factors is a potentially key epigenetic regulator of terminal differentiation in response to cell signaling.
AB - We originally proposed that Ca2+-calmodulin mediates a novel nuclear entry pathway distinct from the canonic Ran-dependent pathway (Sweitzer, T. D., and Hanover, J. A. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 14574-14579). Although seemingly redundant, Ca2+-calmodulin-driven nuclear entry is now known to facilitate nuclear delivery of architectural transcription factors to chromatin. Intriguingly, defects in calmodulin-driven nuclear import of the transcription factors SRY and SOX9 in Sertoli cells lead to human sex reversal diseases with altered male gonad development. Calmodulin-triggered nuclear entry is an evolutionarily ancient feature of eukaryotes observed from yeast to man. Ca2+-calmodulin-triggered nuclear entry of key architectural transcription factors is a potentially key epigenetic regulator of terminal differentiation in response to cell signaling.
UR - http://www.scopus.com/inward/record.url?scp=67649433126&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67649433126&partnerID=8YFLogxK
U2 - 10.1074/jbc.R800076200
DO - 10.1074/jbc.R800076200
M3 - Short survey
C2 - 19126540
AN - SCOPUS:67649433126
SN - 0021-9258
VL - 284
SP - 12593
EP - 12597
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 19
ER -