Calcium signaling and molecular mechanisms underlying neurodegenerative diseases

Ekaterina Pchitskaya, Elena Popugaeva, Ilya Bezprozvanny

Research output: Contribution to journalReview articlepeer-review

204 Scopus citations


Calcium (Ca2+) is a ubiquitous second messenger that regulates various activities in eukaryotic cells. Especially important role calcium plays in excitable cells. Neurons require extremely precise spatial-temporal control of calcium-dependent processes because they regulate such vital functions as synaptic plasticity. Recent evidence indicates that neuronal calcium signaling is abnormal in many of neurodegenerative disorders such as Alzheimer's disease (AD), Huntington's disease (HD) and Parkinson's disease (PD). These diseases represent a major medical, social, financial and scientific problem, but despite enormous research efforts, they are still incurable and only symptomatic relief drugs are available. Thus, new approaches and targets are needed. This review highlight neuronal calcium-signaling abnormalities in these diseases, with particular emphasis on the role of neuronal store-operated Ca2+ entry (SOCE) pathway and its potential relevance as a therapeutic target for treatment of neurodegeneration.

Original languageEnglish (US)
Pages (from-to)87-94
Number of pages8
JournalCell Calcium
StatePublished - Mar 2018


  • Alzheimer disease
  • Ca homeostasis
  • Ca signaling
  • Huntington disease
  • Neurodegeneration
  • Neuronal store-operated Ca channels
  • Neuronal store-operated Ca2+ entry
  • Parkinson disease

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology


Dive into the research topics of 'Calcium signaling and molecular mechanisms underlying neurodegenerative diseases'. Together they form a unique fingerprint.

Cite this