Calcification visibility study using combined high dose and low dose cone beam CT projections

Y. Zhong, C. J. Lai, L. Chen, T. Han, Y. Shen, X. Liu, T. Wang, S. Ge, Y. Yi, Z. You, C. C. Shaw

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Cone beam breast CT technique provides true three dimensional (3D) images of breast anatomy; however the detectability of calcification is limited due to low exposure levels on each projection. In this study, we investigated the possibility of using anisotropic exposure distributions to improve the visibility of calcifications in the breast CT images. Our approach was to measure the CBCT projections with isotropic high and low exposures separately. Reconstruction was performed upon different combinations of these two sets of projection sequences to investigate the visibility change due to the limited-angle high exposure projections. Our preliminary results show that the visibility is improved with the number of high exposure projections in the combinations. In the future we will measure the CBCT projections with anisotropic exposures while keeping the total exposure constant.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2009
Subtitle of host publicationPhysics of Medical Imaging
StatePublished - 2009
EventMedical Imaging 2009: Physics of Medical Imaging - Lake Buena Vista, FL, United States
Duration: Feb 9 2009Feb 12 2009

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherMedical Imaging 2009: Physics of Medical Imaging
Country/TerritoryUnited States
CityLake Buena Vista, FL


  • Cone beam CT
  • Micro-calcification
  • Visibility study
  • X-ray imaging physics

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


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