TY - JOUR
T1 - Calcific aortic valve disease
T2 - A consensus summary from the alliance of investigators on calcific aortic valve disease
AU - Yutzey, Katherine E.
AU - Demer, Linda L.
AU - Body, Simon C.
AU - Huggins, Gordon S.
AU - Towler, Dwight A.
AU - Giachelli, Cecilia M.
AU - Hofmann-Bowman, Marion A.
AU - Mortlock, Douglas P.
AU - Rogers, Melissa B.
AU - Sadeghi, Mehran M.
AU - Aikawa, Elena
N1 - Publisher Copyright:
© 2014 American Heart Association, Inc.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Calcific aortic valve disease (CAVD) is increasingly prevalent worldwide with significant morbidity and mortality. Therapeutic options beyond surgical valve replacement are currently limited. In 2011, the National Heart Lung and Blood Institute assembled a working group on aortic stenosis. This group identified CAVD as an actively regulated disease process in need of further study. As a result, the Alliance of Investigators on CAVD was formed to coordinate and promote CAVD research, with the goals of identifying individuals at risk, developing new therapeutic approaches, and improving diagnostic methods. The group is composed of cardiologists, geneticists, imaging specialists, and basic science researchers. This report reviews the current status of CAVD research and treatment strategies with identification of areas in need of additional investigation for optimal management of this patient population.
AB - Calcific aortic valve disease (CAVD) is increasingly prevalent worldwide with significant morbidity and mortality. Therapeutic options beyond surgical valve replacement are currently limited. In 2011, the National Heart Lung and Blood Institute assembled a working group on aortic stenosis. This group identified CAVD as an actively regulated disease process in need of further study. As a result, the Alliance of Investigators on CAVD was formed to coordinate and promote CAVD research, with the goals of identifying individuals at risk, developing new therapeutic approaches, and improving diagnostic methods. The group is composed of cardiologists, geneticists, imaging specialists, and basic science researchers. This report reviews the current status of CAVD research and treatment strategies with identification of areas in need of additional investigation for optimal management of this patient population.
KW - Aortic valve stenosis
KW - Calcification
KW - Inflammation
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U2 - 10.1161/ATVBAHA.114.302523
DO - 10.1161/ATVBAHA.114.302523
M3 - Review article
C2 - 25189570
AN - SCOPUS:84911913843
SN - 1079-5642
VL - 34
SP - 2387
EP - 2393
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
IS - 11
ER -