Cachectin in tissue injury, shock, and related states

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3 Scopus citations


In the cytokine cascade a central position is occupied by that molecule known as 'cachectin' or 'tumor necrosis factor', because this molecule, more than any other, has been shown to mediate the biologic effects of LPS, and to provoke a state of wasting very similar to that observed in cancer cachexia. The history of the isolation of this factor is instructive, because it illustrates the fact that a single mediator may transduce a broad spectrum of biologic effects, and may thus present itself to investigators interested in very disparate phenomena.

Original languageEnglish (US)
Pages (from-to)353-367
Number of pages15
JournalCritical Care Clinics
Issue number2
StatePublished - 1989

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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