TY - JOUR
T1 - Cachectin in tissue injury, shock, and related states
AU - Beutler, B.
PY - 1989
Y1 - 1989
N2 - In the cytokine cascade a central position is occupied by that molecule known as 'cachectin' or 'tumor necrosis factor', because this molecule, more than any other, has been shown to mediate the biologic effects of LPS, and to provoke a state of wasting very similar to that observed in cancer cachexia. The history of the isolation of this factor is instructive, because it illustrates the fact that a single mediator may transduce a broad spectrum of biologic effects, and may thus present itself to investigators interested in very disparate phenomena.
AB - In the cytokine cascade a central position is occupied by that molecule known as 'cachectin' or 'tumor necrosis factor', because this molecule, more than any other, has been shown to mediate the biologic effects of LPS, and to provoke a state of wasting very similar to that observed in cancer cachexia. The history of the isolation of this factor is instructive, because it illustrates the fact that a single mediator may transduce a broad spectrum of biologic effects, and may thus present itself to investigators interested in very disparate phenomena.
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U2 - 10.1016/s0749-0704(18)30441-x
DO - 10.1016/s0749-0704(18)30441-x
M3 - Review article
C2 - 2650822
AN - SCOPUS:0024599151
SN - 0749-0704
VL - 5
SP - 353
EP - 367
JO - Critical Care Clinics
JF - Critical Care Clinics
IS - 2
ER -