Cachectin and tumour necrosis factor as two sides of the same biological coin

Bruce Beutler; Anthony Cerami

doi:10.1038/320584a0

Cachectin and tumour necrosis factor as two sides of the same biological coin

Bruce Beutler, Anthony Cerami

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Abstract

In response to invasive stimuli, macrophages secrete cachectin, a multipotent protein. Prominent among its biological effects is the ability to induce wasting (cachexia) as well as a lethal state of shock. The identity of cachectin and tumour necrosis factor has led to a new view of its therapeutic potential.

Original language	English (US)
Pages (from-to)	584-588
Number of pages	5
Journal	Nature
Volume	320
Issue number	6063
DOIs	https://doi.org/10.1038/320584a0
State	Published - 1986

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title = "Cachectin and tumour necrosis factor as two sides of the same biological coin",

abstract = "In response to invasive stimuli, macrophages secrete cachectin, a multipotent protein. Prominent among its biological effects is the ability to induce wasting (cachexia) as well as a lethal state of shock. The identity of cachectin and tumour necrosis factor has led to a new view of its therapeutic potential.",

author = "Bruce Beutler and Anthony Cerami",

year = "1986",

doi = "10.1038/320584a0",

language = "English (US)",

volume = "320",

pages = "584--588",

journal = "Nature",

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T1 - Cachectin and tumour necrosis factor as two sides of the same biological coin

AU - Beutler, Bruce

AU - Cerami, Anthony

PY - 1986

Y1 - 1986

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AB - In response to invasive stimuli, macrophages secrete cachectin, a multipotent protein. Prominent among its biological effects is the ability to induce wasting (cachexia) as well as a lethal state of shock. The identity of cachectin and tumour necrosis factor has led to a new view of its therapeutic potential.

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DO - 10.1038/320584a0

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JO - Nature

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IS - 6063

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Cachectin and tumour necrosis factor as two sides of the same biological coin

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