C 60-fullerene binds with the ATP binding domain of human DNA topoiosmerase II alpha

Lokesh Baweja, Deepak Gurbani, Rishi Shanker, Alok K. Pandey, V. Subramanian, Alok Dhawan

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


C 60-fullerene has promising biological applications, such as drug delivery, biosensors, diagnosis and theraupetics. Despite of these applications, several in vitro studies have also reported the DNA damaging potential of this nanomaterial. Though, very little is known about the mechanism involved behind the fullerene mediated DNA damage. Our study was aimed at identifying the binding site of fullerene in the ATP binding domain of human topoisomerase II alpha, a major enzyme involved in maintaining DNA topology. In silico studies of fullerene with the enzyme demonstrated that it can interact with the active site residues of this enzyme through hydrophobic, pi-stacking and van der Waals interactions and could inhibit the activity of this enzyme.

Original languageEnglish (US)
Pages (from-to)177-178
Number of pages2
JournalJournal of biomedical nanotechnology
Issue number1
StatePublished - Jan 2011
Externally publishedYes


  • DNA damage
  • Fullerenes
  • Human DNA topoisomerase II alpha
  • Nanomaterials

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • General Materials Science
  • Pharmaceutical Science


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