TY - JOUR
T1 - Brucella abortus DNA is a major bacterial agonist to activate the host innate immune system
AU - Campos, Priscila Carneiro
AU - Gomes, Marco Túlio Ribeiro
AU - Guimarães, Gabriela
AU - Costa Franco, Miriam Maria Silva
AU - Marim, Fernanda Martins
AU - Oliveira, Sergio Costa
N1 - Funding Information:
This work was supported by grants from CNPq , CNPq/CONICET (#490398/2010-3), FAPEMIG , Fapemig/CNPq (PRONEX, #APQ-04003-10), CAPES/PNPD , CNPq/CT-Biotec (#402527/2013-5), CNPq/Repensa (#562139/2010-9) and INCT-Vacinas .
Publisher Copyright:
© 2014 Institut Pasteur.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Immunity against Brucella abortus depends on the recognition of pathogen-associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs). Signaling pathways triggered by Brucella DNA involves TLR9, AIM2 and possibly STING and MAVS. Herein, we review the advances in B. abortus DNA sensing by host innate immune receptors and the progress in this field.
AB - Immunity against Brucella abortus depends on the recognition of pathogen-associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs). Signaling pathways triggered by Brucella DNA involves TLR9, AIM2 and possibly STING and MAVS. Herein, we review the advances in B. abortus DNA sensing by host innate immune receptors and the progress in this field.
KW - Bacterial DNA
KW - Brucella abortus
KW - Cytosolic sensors
KW - Innate immunity
KW - TLRs
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U2 - 10.1016/j.micinf.2014.08.010
DO - 10.1016/j.micinf.2014.08.010
M3 - Article
C2 - 25173577
AN - SCOPUS:84919335489
SN - 1286-4579
VL - 16
SP - 979
EP - 984
JO - Microbes and Infection
JF - Microbes and Infection
IS - 12
ER -