Brief report: No evidence for parvovirus B19 or hepatitis E virus as a cause of acute liver failure

W. M. Lee, K. E. Brown, N. S. Young, G. J. Dawson, G. G. Schlauder, R. A. Gutierrez, R. Fontana, L. Rossaro, T. Davern, E. Lalani

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Viral hepatitis A and B are known to cause acute liver failure. While nearly 20% of acute liver failure cases are of indeterminate etiology, screening for other viruses has not been uniformly performed. We looked for evidence for parvovirus B19 and hepatitis E virus in sera from U.S. acute liver failure patients. For B19, 78 patients' sera, including 34 with indeterminate etiology, were evaluated by DNA dot-blot hybridization, reverse transcription polymerase chain reaction, and enzyme-linked immunosorbent assay for immunoglobin G and M antibodies; none showed evidence for infection. In like manner, 126 patients' sera were analyzed for hepatitis E virus RNA by reverse transcription polymerase chain reaction and for hepatitis E virus immunoglobin G and Mantibodies by enzyme-linked immunosorbent assay; no acute hepatitis E virus cases were identified. If a unique acute liver failure virus exists, it is neither of these candidate agents.

Original languageEnglish (US)
Pages (from-to)1712-1715
Number of pages4
JournalDigestive Diseases and Sciences
Issue number10
StatePublished - Oct 2006


  • Acute liver failure
  • Encephalopathy
  • Hepatitis E virus
  • Parvovirus B19
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology


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