TY - JOUR
T1 - Bridging the gap
T2 - Membrane contact sites in signaling, metabolism, and organelle dynamics
AU - Prinz, William A.
PY - 2014
Y1 - 2014
N2 - Regions of close apposition between two organelles, often referred to as membrane contact sites (MCSs), mostly form between the endoplasmic reticulum and a second organelle, although contacts between mitochondria and other organelles have also begun to be characterized. Although these contact sites have been noted since cells first began to be visualized with electron microscopy, the functions of most of these domains long remained unclear. The last few years have witnessed a dramatic increase in our understanding of MCSs, revealing the critical roles they play in intracellular signaling, metabolism, the trafficking of metabolites, and organelle inheritance, division, and transport.
AB - Regions of close apposition between two organelles, often referred to as membrane contact sites (MCSs), mostly form between the endoplasmic reticulum and a second organelle, although contacts between mitochondria and other organelles have also begun to be characterized. Although these contact sites have been noted since cells first began to be visualized with electron microscopy, the functions of most of these domains long remained unclear. The last few years have witnessed a dramatic increase in our understanding of MCSs, revealing the critical roles they play in intracellular signaling, metabolism, the trafficking of metabolites, and organelle inheritance, division, and transport.
UR - http://www.scopus.com/inward/record.url?scp=84903157796&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84903157796&partnerID=8YFLogxK
U2 - 10.1083/jcb.201401126
DO - 10.1083/jcb.201401126
M3 - Review article
C2 - 24958771
AN - SCOPUS:84903157796
SN - 0021-9525
VL - 205
SP - 759
EP - 769
JO - Journal of Cell Biology
JF - Journal of Cell Biology
IS - 6
ER -