Breast tumor vascular oxygenation and blood volume assessed by near-infrared spectroscopy and magnetic resonance

Yueqing Gu; Vikram Kodibagkar; Mengna Xia; Anca Constantinescu; Ralph P. Mason; Hanli Liu

doi:10.1117/12.591939

Breast tumor vascular oxygenation and blood volume assessed by near-infrared spectroscopy and magnetic resonance

Yueqing Gu, Vikram Kodibagkar, Mengna Xia, Anca Constantinescu, Ralph P. Mason, Hanli Liu

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The goal of this study is to evaluate the feasibility of Near Infrared Spectroscopy (NIRS) as an in vivo monitoring tool for rat breast tumor oxygenation and vascular blood volume by comparison with the established modalities, magnetic resonance imaging/spectroscopy (MRI/MRS). The changes in oxygenated hemoglobin concentration and total hemoglobin concentration (Δ[HbO ₂], Δ[Hb] _total) with respect to hyperoxic gas interventions were monitored by NIRS. Changes in deoxygenated hemoglobin, a blood oxygenation level dependent (BOLD) contrast, and blood volume on breast tumors were monitored by BOLD MRI and 9F MRS of PFOB, respectively. Results showed strong consistency among the two pairs: Δ[HbO ₂] versus BOLD signal, Δ[Hb] _total versus tumor blood volume. These consistent results demonstrated the ability of NIRS as a valid in-vivo real time monitoring tool for studying the dynamic responses of Δ[HbO ₂] and Δ[Hb] _total to therapeutic interventions applied to rat breast tumors. Furthermore, the results suggested that NIRS and MRS are complimentary with each other in terms of temporal and spatial resolutions.

Original language	English (US)
Title of host publication	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Editors	B. Chance, M. Chen, A.E.T. Chiou, Q. Luo
Pages	918-925
Number of pages	8
Volume	5630 II
DOIs	https://doi.org/10.1117/12.591939
State	Published - 2005
Event	Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II - Beijing, China Duration: Nov 8 2004 → Nov 12 2004

Other

Other	Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II
Country/Territory	China
City	Beijing
Period	11/8/04 → 11/12/04

Keywords

Breast tumor
Carbogen intervention
MRI and MRS
NIRS
Tumor blood volume
Tumor oxygenation

ASJC Scopus subject areas

General Engineering

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10.1117/12.591939

Cite this

Gu, Y., Kodibagkar, V., Xia, M., Constantinescu, A., Mason, R. P., & Liu, H. (2005). Breast tumor vascular oxygenation and blood volume assessed by near-infrared spectroscopy and magnetic resonance. In B. Chance, M. Chen, A. E. T. Chiou, & Q. Luo (Eds.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 5630 II, pp. 918-925). Article 181 https://doi.org/10.1117/12.591939

Breast tumor vascular oxygenation and blood volume assessed by near-infrared spectroscopy and magnetic resonance. / Gu, Yueqing; Kodibagkar, Vikram; Xia, Mengna et al.
Progress in Biomedical Optics and Imaging - Proceedings of SPIE. ed. / B. Chance; M. Chen; A.E.T. Chiou; Q. Luo. Vol. 5630 II 2005. p. 918-925 181.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Gu, Y, Kodibagkar, V, Xia, M, Constantinescu, A, Mason, RP & Liu, H 2005, Breast tumor vascular oxygenation and blood volume assessed by near-infrared spectroscopy and magnetic resonance. in B Chance, M Chen, AET Chiou & Q Luo (eds), Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 5630 II, 181, pp. 918-925, Optics in Health Care and Biomedical Optics: Diagnostics and Treatment II, Beijing, China, 11/8/04. https://doi.org/10.1117/12.591939

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abstract = "The goal of this study is to evaluate the feasibility of Near Infrared Spectroscopy (NIRS) as an in vivo monitoring tool for rat breast tumor oxygenation and vascular blood volume by comparison with the established modalities, magnetic resonance imaging/spectroscopy (MRI/MRS). The changes in oxygenated hemoglobin concentration and total hemoglobin concentration (Δ[HbO 2], Δ[Hb] total) with respect to hyperoxic gas interventions were monitored by NIRS. Changes in deoxygenated hemoglobin, a blood oxygenation level dependent (BOLD) contrast, and blood volume on breast tumors were monitored by BOLD MRI and 9F MRS of PFOB, respectively. Results showed strong consistency among the two pairs: Δ[HbO 2] versus BOLD signal, Δ[Hb] total versus tumor blood volume. These consistent results demonstrated the ability of NIRS as a valid in-vivo real time monitoring tool for studying the dynamic responses of Δ[HbO 2] and Δ[Hb] total to therapeutic interventions applied to rat breast tumors. Furthermore, the results suggested that NIRS and MRS are complimentary with each other in terms of temporal and spatial resolutions. ",

keywords = "Breast tumor, Carbogen intervention, MRI and MRS, NIRS, Tumor blood volume, Tumor oxygenation",

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AB - The goal of this study is to evaluate the feasibility of Near Infrared Spectroscopy (NIRS) as an in vivo monitoring tool for rat breast tumor oxygenation and vascular blood volume by comparison with the established modalities, magnetic resonance imaging/spectroscopy (MRI/MRS). The changes in oxygenated hemoglobin concentration and total hemoglobin concentration (Δ[HbO 2], Δ[Hb] total) with respect to hyperoxic gas interventions were monitored by NIRS. Changes in deoxygenated hemoglobin, a blood oxygenation level dependent (BOLD) contrast, and blood volume on breast tumors were monitored by BOLD MRI and 9F MRS of PFOB, respectively. Results showed strong consistency among the two pairs: Δ[HbO 2] versus BOLD signal, Δ[Hb] total versus tumor blood volume. These consistent results demonstrated the ability of NIRS as a valid in-vivo real time monitoring tool for studying the dynamic responses of Δ[HbO 2] and Δ[Hb] total to therapeutic interventions applied to rat breast tumors. Furthermore, the results suggested that NIRS and MRS are complimentary with each other in terms of temporal and spatial resolutions.

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Breast tumor vascular oxygenation and blood volume assessed by near-infrared spectroscopy and magnetic resonance

Abstract

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Keywords

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