Abstract
Three oxygen-sensitive parameters (arterial hemoglobin oxygen saturation SaO 2, tumor vascular oxygenated hemoglobin concentration [HbO 2], and tumor oxygen tension pO 2) were measured simultaneously by three different optical techniques (pulse oximeter, near infrared spectroscopy, and FOXY™) to evaluate dynamic responses of breast tumors to carbogen (5% CO 2 and 95% O 2) intervention. All three parameters displayed similar trends in dynamic response to carbogen challenge, but with different response times. These response times were quantified by the time constants of the exponential fitting curves, revealing the immediate and the fastest response from the arterial SaO 2, followed by changes in global tumor vascular [HbO 2], and delayed responses for pO 2. The consistency of the three oxygen-sensitive parameters demonstrated the ability of NIRS to monitor therapeutic interventions for rat breast tumors in-vivo in real time.
Original language | English (US) |
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Title of host publication | Proceedings of SPIE - The International Society for Optical Engineering |
Editors | B. Chance, R.R. Alfano, B.J. Tromberg, M. Tamura, E.M. Sevick-Muraca |
Pages | 416-423 |
Number of pages | 8 |
Volume | 4955 |
DOIs | |
State | Published - 2003 |
Event | PROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Optical Tomography and Spectroscopy of Tissue V - San Jose, CA, United States Duration: Jan 26 2003 → Jan 29 2003 |
Other
Other | PROGRESS IN BIOMEDICAL OPTICS AND IMAGING: Optical Tomography and Spectroscopy of Tissue V |
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Country/Territory | United States |
City | San Jose, CA |
Period | 1/26/03 → 1/29/03 |
Keywords
- Breast tumor
- Carbogen intervention
- Fluorescence quenching
- NIRS
- Tumor oxygenation
ASJC Scopus subject areas
- Electrical and Electronic Engineering
- Condensed Matter Physics